Ingredient compliance data extraction (CAS 532-32-1) is a cosmetic cosmetic ingredient functioning as Emulsifier. NOAEL 1795 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
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Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ingredient compliance data extraction.
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Toxicological Studies
10 study endpoints found for Ingredient compliance data extraction. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
Endpoint
Value
Route
Species
Study Type
Source
NOAEL
175 mg/kg bw/day
oral
mouse
Developmental
COSMOS_DB
NOAEL
250 mg/kg bw/day
oral
rabbit
Developmental
COSMOS_DB
NOAEL
300 mg/kg bw/day
oral
hamster
Developmental
COSMOS_DB
NOAEL
510 mg/kg bw/day
oral
rat
Developmental
COSMOS_DB
NOAEL
1095 mg/kg bw/day
oral
rat
Carcinogenicity
COSMOS_DB
NOAEL
1250 mg/kg bw/day
oral
rat
Subchronic
COSMOS_DB
NOAEL
2000 mg/kg bw/day
oral
rat
Short Term Toxicity
COSMOS_DB
NOAEL
2090 mg/kg bw/day
oral
rat
Short Term Toxicity
COSMOS_DB
NOAEL
=3.6 mg/kg bw/day
oral
-
Toxicology study
INCHEM_WHO_jecfa_jecmono_v1037je01
NOAEL
=3.6 mg/kg bw/day
oral
-
Toxicology study
INCHEM_WHO_jecfa_jecmono_v1037je01
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is mildly irritating to the eyes.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Ingredient compliance data extraction across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
Endpoint
Value
Species
Route
Duration
Source
NOAEL
=1310 mg/kg-day
Rat
oral
-
EFSA
NOAEL
=500 mg/kg-day
Rat
oral
-
EFSA
LEL
=36000 mg/kg-day
Pig
oral
subchronic
EFSA
LEL
=36000 mg/kg-day
Pig
oral
subchronic
EFSA
LEL
=36000 mg/kg-day
Pig
oral
-
EFSA
NOEL
=1000 mg/kg-day
Mouse
oral
acute
ECOTOX
NOAEL
=250 mg/kg-day
Rabbit
oral
-
ECHA IUCLID
NOAEL
=905 mg/kg-day
Rat
oral
short-term
ECHA IUCLID
NOAEL
=3571 mg/kg-day
Mouse
oral
short-term
ECHA IUCLID
NOAEL
=1000 mg/kg-day
Rat
oral
subchronic
ECHA IUCLID
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category:preservative
Receptor targets:ERα (weak, limited)
LOEC:N/A
EU status:allowed (max 0.5%)
weak modulator
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
JPKR Japan/Korea Cosmetics
Japan (Positive (Preservative)): max 1.0
Additional Jurisdictional Restrictions (4)
Jurisdiction
Status
Max %
Product Type
CN
permitted_preservative
0.5
All cosmetics
IN
permitted_preservative
0.5
all products (other benzoate salts/esters)
AU
restricted
-
preservatives
BR
permitted_preservative
2.5 (rinse) / 1.7 (oral) / 0.5 (leave-on)
Same as Benzoic Acid (calculated as acid)
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (1 records across 5 sources)
Type
DA %
Method
Skin Model
SCCS Ref
measured_sccs_opinion
42.6%
-
-
SCCP/0891/05
Function Categories & List Membership
Cosmetic/Chemical Function Categories
AntioxidantBiocideCorrosion inhibitorCrystal growth modifiers (nucleating agents)DeodorizerDyeFlavouring and nutrientFlocculating agentFood preservativeFragrance
Regulatory List Membership (5)
EU Regulated in Personal CareEU Restricted for Children (Cosmetics)IFRA Fragrance Transparency ListEPA Safer Chemical Ingredients List (SCIL)FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Ingredient compliance data extraction.
SCIL (9/2019)Canada; consumer_product; Substances in Products - Canada (4/2014)inert_ingredient; Pesticidesinert_ingredient; Pesticidesinert_ingredient; non_food_use; PesticidesEurope; Personal care - body hygiene - hand soapactive_ingredient; Europe; Pesticidesdetected; general_crops; Pesticides; residueEurope; Personal carechildren; Europe; Personal carechildren; Europe; Personal carechildren; Europe; Personal care - body hygiene - body washchildren; Europe; Personal care - hair styling and care - shampoochildren; Europe; Personal care - specialized bath products - bubble bathchildren; Europe; Personal care - dental care - toothpastechildren; Europe; Personal carechildren; Europe; Personal carechildren; Europe; Personal care
Australian Status
AICIS status:listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCEChEMBL / DrugCentral / FAERSDB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Is Ingredient compliance data extraction safe in cosmetics?
Ingredient compliance data extraction has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Is Ingredient compliance data extraction allowed in the EU?
Ingredient compliance data extraction EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ingredient compliance data extraction do in cosmetics?
Ingredient compliance data extraction functions as: Emulsifier. It is classified as a cosmetic ingredient in our database. CAS number: 532-32-1.
What is the NOAEL for Ingredient compliance data extraction?
The NOAEL (No Observed Adverse Effect Level) for Ingredient compliance data extraction is 175 mg/kg bw/day based on a Developmental study via oral route in mouse. A total of 10 study endpoints are available. Source: COSMOS_DB.
Is Ingredient compliance data extraction used outside cosmetics?
Ingredient compliance data extraction also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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