Also known as: 2-Phenylpropanal, Benzeneacetaldehyde, .alpha.-methyl-, Benzeneacetaldehyde, alpha-methyl-, Benzeneacetalaldehyde, alpha-methyl-, EINECS 202-255-5 (+14 more)
INCI: HYDRATROPIC ALDEHYDE
Hydratropic Aldehyde (2-Phenylpropanal) (CAS 93-53-8) is a cosmetic cosmetic ingredient functioning as Fragrance. NOAEL 10 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 93-53-8 →
Hydratropic Aldehyde (2-Phenylpropanal) is classified GHS CMR hazard (H315, H317, H319, H361) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Hydratropic Aldehyde (2-Phenylpropanal).
Calculate MoS for your specific formulation with the MoS Calculator.
3 study endpoints found for Hydratropic Aldehyde (2-Phenylpropanal). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 10 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | =10 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =25 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Pre-calculated NOAEL → SED → MoS audit trail for Hydratropic Aldehyde (2-Phenylpropanal) across SCCS product categories, with measured dermal absorption where available.
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
Source: LLNA: Gerberick et al. (2005); DPRA: Bauch et al. 2012 [DOI:10.1016/j.yrtph.2012.05.013] | Gerberick et al. 2007 [DOI:10.1093/toxsci/kfm064]; KS: Bauch et al. 2012 [DOI:10.1016/j.yrtph.2012.05.013] | Joint Research Centre of the European Union 2014; hCLAT: Bauch et al. 2012 [DOI:10.1016/j.yrtph.2012.05.013] | Nukada et al. 2013 [DOI:10.1016/j.tiv.2012.11.006]; HPPT: [151] Kligman AM (1971): Report to RIFM, 2 April, unpublished.
3 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 1296 | - | - |
| HRIPT | - | 0 | 1550 | - | - |
| OECD_DA_Human | - | 0 | - | - | 1B (Weak sensitizer) |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Expert safety assessment and concern-level summary for Hydratropic Aldehyde (2-Phenylpropanal).
Public NOAEL study rows linked to Hydratropic Aldehyde (2-Phenylpropanal) by CAS number or substance name.
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
Hydratropic Aldehyde (2-Phenylpropanal) has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
Hydratropic Aldehyde (2-Phenylpropanal) EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
Hydratropic Aldehyde (2-Phenylpropanal) functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 93-53-8.
The NOAEL (No Observed Adverse Effect Level) for Hydratropic Aldehyde (2-Phenylpropanal) is 10 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 3 study endpoints are available. Source: COSMOS_DB.
Hydratropic Aldehyde (2-Phenylpropanal) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Hydratropic Aldehyde (2-Phenylpropanal) is classified GHS CMR hazard (H315, H317, H319, H361) in the chemicals database but is restricted in EU cosmetics.
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