Is Hinokitiol safe in cosmetics?
Hinokitiol has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Hinokitiol
Also known as: 4-08-00-00488, BRN 2045206, EINECS 207-880-7, Hinokitol, beta-Isopropyltropolon (+5 more)
INCI: HINOKITIOL
Hinokitiol (CAS 499-44-5) is a cosmetic cosmetic ingredient functioning as Antimicrobial, anti-dandruff agent, anti-inflammatory, hair conditioning,. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 499-44-5 →
Auto-generated CPSR Part A draft with source citations
Function
Antimicrobial, anti-dandruff agent, anti-inflammatory, hair conditioning, antistatic
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-hydroxy-6-propan-2-ylcyclohepta-2,4,6-trien-1-one
InChIKey
FUWUEFKEXZQKKA-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not a monographed sunscreen active, no FDA restrictions identified.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hinokitiol.
Calculate MoS for your specific formulation with the MoS Calculator.
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
JPKR Japan/Korea Cosmetics
Japan (Positive (Preservative)): max 0.10
Japan (Restricted): max Wash-away: No limit | Leave-on: 0.10% | Mucosa: 0.050%
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| JP | restricted | Wash-away: No limit | Leave-on: 0.10% | Mucosa: 0.050% | Wash-away: No limit | Leave-on: 0.10% | Mucosa: 0.050% |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Fragrance
Softener and conditioner
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for Hinokitiol.
Regulatory Flags
ifra_fragrance
Known Synonyms
4-08-00-00488
BRN 2045206
EINECS 207-880-7
Hinokitol
beta-Isopropyltropolon
THUJAPLICIN, BETA
beta-Thujaplicine
Tropolone, 4-isopropyl-
UNII-U5335D6EBI
Hyka 1
Chemical Function
Anti-static agent
Softener and conditioner
Fragrance
Regulatory Lists
IFRA Transparency
active_ingredient; Europe; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
HINOKITIOL
ChEMBL ID
CHEMBL48310
Frequently Asked Questions
Is Hinokitiol allowed in the EU?
Hinokitiol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hinokitiol do in cosmetics?
Hinokitiol functions as: Antimicrobial, anti-dandruff agent, anti-inflammatory, hair conditioning, antistatic. It is classified as a cosmetic ingredient in our database. CAS number: 499-44-5.
Is Hinokitiol used outside cosmetics?
Hinokitiol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Hinokitiol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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