Is Hexyl Acetate safe in cosmetics?
Hexyl Acetate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Hexyl Acetate
Also known as: 4-02-00-00159, BRN 1747138, EINECS 205-572-7, FEMA No. 2565, l-Hexyl acetate (+2 more)
INCI: HEXYL ACETATE
Hexyl Acetate (CAS 142-92-7) is a cosmetic cosmetic ingredient functioning as Fragrance, Flavouring. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 142-92-7 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance, Flavouring
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
hexyl acetate
InChIKey
AOGQPLXWSUTHQB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FEMA GRAS #2565; CIR safe as used in 2012
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexyl Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2592 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
fragrance_ifra
{"cas_number": "142-92-7", "ifra_amendment_number": "49", "ifra_restriction_type": "Restricted", "ifra_max_use_level_category_1_pct": "0.14", "ifra_max_use_level_category_4_pct": "2.2", "ifra_max_use_level_category_7_pct": "0.32", "ifra_max_use_level_category_11_pct": "0.065", "eu_allergen_declaration_required": "No", "eu_26_allergens_list": "No", "sccs_opinion_available": "Yes", "sensitization_po…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
A skin and eye irritant.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Number
128
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
HEXYL ACETATE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/52 | FAS 40-JECFA 49/297
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Hexyl Acetate.
Regulatory Flags
epa_safer_alternative
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Hexyl Acetate by CAS number or substance name.
Studies
9
Lowest NOAEL
100 mg/kg bw/day
Highest NOAEL
500 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
4-02-00-00159
BRN 1747138
EINECS 205-572-7
FEMA No. 2565
l-Hexyl acetate
Hexylester kyseliny octove
UNII-7U7KU3MWT0
Chemical Function
Fragrance
Deodorizer
Flavouring and nutrient
Regulatory Lists
air; detected; emissions; Europe; Toys and children's products
air; Cleaning products and household care - air freshener; detected; emissions
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
consumer_product
air; Cleaning products and household care - air freshener; detected; emissions; Europe
air; detected; emissions; Europe; Toys and children's products
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
HEXYL ACETATE
ChEMBL ID
CHEMBL2228454
Frequently Asked Questions
Is Hexyl Acetate allowed in the EU?
Hexyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexyl Acetate do in cosmetics?
Hexyl Acetate functions as: Fragrance, Flavouring. It is classified as a cosmetic ingredient in our database. CAS number: 142-92-7.
Is Hexyl Acetate used outside cosmetics?
Hexyl Acetate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Hexyl Acetate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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