Is Hexamethylindanopyran safe in cosmetics?
Hexamethylindanopyran has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted.
Hexamethylindanopyran
INCI: HEXAMETHYLINDANOPYRAN
Hexamethylindanopyran (CAS 1222-05-5 (also known as Galaxolide® / HHCB)) is a cosmetic cosmetic ingredient functioning as Perfuming / fragrance. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 1222-05-5 (also known as Galaxolide® / HHCB) →
Auto-generated CPSR Part A draft with source citations
Function
Perfuming / fragrance
Safety Rating
POOR
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted — no specific CFR restriction currently in force
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexamethylindanopyran.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for Hexamethylindanopyran based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.1%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
IFRA Restricted
Source: EU 2023/1545; SCCS/1459/11
Additional Ingredient Properties
1 property record from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "yes", "allergen_class": "fragrance", "patch_test_frequency_pct": "0.1", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "yes", "source": "EU 2023/1545; SCCS/1459/11"}
Expert Verdict
Expert safety assessment and concern-level summary for Hexamethylindanopyran.
Regulatory Flags
fragrance-component
Frequently Asked Questions
Is Hexamethylindanopyran allowed in the EU?
Hexamethylindanopyran EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexamethylindanopyran do in cosmetics?
Hexamethylindanopyran functions as: Perfuming / fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 1222-05-5 (also known as Galaxolide® / HHCB).
Compliance Tools
Check Hexamethylindanopyran compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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