Is Heptanal safe in cosmetics?
Heptanal has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Heptanal
Also known as: n-Heptanal, heptaldehyde, BRN 1560236, EINECS 203-898-4, FEMA No. 2540 (+10 more)
Heptanal (CAS 111-71-7) is a cosmetic cosmetic ingredient functioning as Flavouring and nutrient; Fragrance. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 111-71-7 →
Auto-generated CPSR Part A draft with source citations
Function
Flavouring and nutrient; Fragrance
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
heptanal
InChIKey
FXHGMKSSBGDXIY-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Heptanal.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Heptanal. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Heptanal across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2592 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Skin Eye Respiratory Irritation
... The halogenated aliphatic aldehydes, and the unsaturated aldehydes are particularly irritating. The mucus membranes of the nasal and oral passages and the upper respiratory tract are affected, ... . /Aldehydes/
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (3)
JECFA Number
95
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ALDEHYDE C-7 | 2002 | No safety concern at current levels of intake when used as a flavouring agent | Secondary components do not raise a safety concern | TRS 913-JECFA 59/111 | FAS 40-JECFA 49/147 (1997)
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
HEPTANAL | 2002 | No safety concern at current levels of intake when used as a flavouring agent | Secondary components do not raise a safety concern | TRS 913-JECFA 59/111 | FAS 40-JECFA 49/147 (1997)
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Heptanal.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Heptanal by CAS number or substance name.
Studies
10
Lowest NOAEL
300 mg/kg bw/day
Highest NOAEL
1750 mg/kg bw/day
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
n-Heptanal
heptaldehyde
BRN 1560236
EINECS 203-898-4
FEMA No. 2540
FEMA Number 2541
Heptylaldehyde
UNII-92N104S3HF
1-Heptanal
Aldehyde C7
FEMA 2540
Heptan-1-al
N-C6H13CHO
N-Heptaldehyde [UN3056] [Flammable liquid]
Oenanthole
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
air; detected; emissions; Europe; Toys and children's products
air; Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; emissions; Europe
air; detected; emissions; Europe; Other direct contact consumer goods
air; detected; emissions; Europe; Toys and children's products
air; detected; emissions; Europe; Toys and children's products
air; detected; emissions; Europe; Toys and children's products
air; detected; emissions; Europe; Other direct contact consumer goods
detected; Europe; Other direct contact consumer goods
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
HEPTANAL
ChEMBL ID
CHEMBL18104
Frequently Asked Questions
Is Heptanal allowed in the EU?
Heptanal EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Heptanal do in cosmetics?
Heptanal functions as: Flavouring and nutrient; Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 111-71-7.
What is the NOAEL for Heptanal?
The NOAEL (No Observed Adverse Effect Level) for Heptanal is =1000 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Heptanal used outside cosmetics?
Heptanal also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Heptanal compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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