What is the NOAEL for Heptanal?
Heptanal has 62 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Heptanal
Also known as: n-Heptanal, heptaldehyde, BRN 1560236, EINECS 203-898-4, FEMA No. 2540 (+10 more)
CAS 111-71-7
Heptanal (CAS 111-71-7) is a chemical substance. Key regulatory status: REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
62
SOURCE
chemical inventory jurisdictions
Regulatory lists
12
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
21 fields
Name
Heptanal
CAS Number
111-71-7
DTXSID
DTXSID0021597
Molecular Formula
C7H14O
InChI Key
FXHGMKSSBGDXIY-UHFFFAOYSA-N
Monoisotopic Mass
114.104465
Synonyms
n-HeptanalheptaldehydeBRN 1560236EINECS 203-898-4FEMA No. 2540FEMA Number 2541HeptylaldehydeUNII-92N104S3HF1-HeptanalAldehyde C7FEMA 2540Heptan-1-al
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
13 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
12 records
| List | Keyword | Source |
|---|---|---|
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 62 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 19.8348560906589 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 73.6087999579639 | uM | ACC | - | - | NTP_ICE_endocrine |
| =98.7 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 4.2 | min | ET50 | Dermal | - | NTP_ICE_skin_irritation |
| 4.5 | min | ET50 | Dermal | - | NTP_ICE_skin_irritation |
| 6.5 | min | ET50 | Dermal | - | NTP_ICE_skin_irritation |
| 7.3 | min | ET50 | Dermal | - | NTP_ICE_skin_irritation |
| 8.1 | min | ET50 | Dermal | - | NTP_ICE_skin_irritation |
| 8.3 | min | ET50 | Dermal | - | NTP_ICE_skin_irritation |
| 13.8 | min | ET50 | Dermal | - | NTP_ICE_skin_irritation |
| 16.1 | min | ET50 | Dermal | - | NTP_ICE_skin_irritation |
| 16.2 | min | ET50 | Dermal | - | NTP_ICE_skin_irritation |
| 20.2 | min | ET50 | Dermal | - | NTP_ICE_skin_irritation |
| 125 | min | ET50 | Dermal | - | NTP_ICE_skin_irritation |
| 92N104S3HF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 92N104S3HF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 92N104S3HF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 92N104S3HF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2592 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >18.4 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =3200 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =14000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =150 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_HPVIS |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0319 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =37 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
| =500 | mg/kg bw/day | NOAEL | dermal | Rabbit | ToxValDB_HPVIS |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =2050 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
| 58.6 | % | Positive reaction | Dermal | Human | NTP_ICE_skin_irritation |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| =0.003 | mg/m3 | RfC | inhalation | Human | ToxValDB_RSL |
| =0.03 | mg/m3 | RfC | inhalation | Human | ToxValDB_RSL |
| 5.4 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 6.49 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 7.1 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 8 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 8.1 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 8.2 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 8.4 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 8.6 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 9.1 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 9.8 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 10 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 10.4 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 12.8 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 13.3 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 13.7 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
Showing 50 of 62 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Heptanal | 203-898-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
HEPTANAL
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Heptanal?
Heptanal appears on 8 regulatory/inventory lists including air; detected; emissions; Europe; Toys and children's products, air; Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; emissions; Europe, air; detected; emissions; Europe; Other direct contact consumer goods, and 5 more. Source: EPA CPDat.
Is Heptanal used in cosmetics?
Yes, Heptanal is also indexed as a cosmetic ingredient under the name Heptanal. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Heptanal come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Heptanal used outside industrial chemicals?
Heptanal also appears in cosmetics, pharmaceutical, cannabis databases.