Is Aminoethylethanolamine safe in cosmetics?
Aminoethylethanolamine has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Aminoethylethanolamine
Also known as: Ethanol, 2-[(2-aminoethyl)amino]-, 4-04-00-01558, N-Aminoethyl ethanolamine, 2-((2-Aminoethyl)amino)ethanol, N-Aminoethylethanolamine (+12 more)
INCI: AMINOETHYLETHANOLAMINE
Aminoethylethanolamine (CAS 111-41-1) is a cosmetic cosmetic ingredient functioning as Buffering. Reported NOAEL =50 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 111-41-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Aminoethylethanolamine is classified GHS Danger (H290, H314, H317, H318, H335, H360, H334, H373) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Buffering
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-(2-aminoethylamino)ethanol
InChIKey
LHIJANUOQQMGNT-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically restricted by FDA; ethanolamine derivatives reviewed by CIR under broader amine categories
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Aminoethylethanolamine.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Aminoethylethanolamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =50 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =250 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Health HazardCorrosiveHarmful / Irritant
Hazard Class and Category
Repr. 1B; Skin Corr. 1B; Skin Sens. 1
Hazard Statements
- H360Df
- H314 Causes severe skin burns and eye damage
- H317 May cause an allergic skin reaction
Specific Concentration Limits / M-factors
STOT SE 3; H335: C ≥ 5.0%
Inserted via ATP: ATP01corr
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1471
(EU) 2019/831
CMR: Reprotoxic Cat. 1B()
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1471
BRIN Brazil/India Cosmetics
India: Prohibited (GNRAS)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Hardener
No specific technical function
Regulatory List Membership (3)
EU Banned in Cosmetics
FDA Indirect Food Contact Additives
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Aminoethylethanolamine.
Regulatory Flags
eu_banned_cosmetics
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Aminoethylethanolamine by CAS number or substance name.
Studies
2
Lowest NOAEL
50 mg/kg bw/day
Highest NOAEL
250 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Ethanol, 2-[(2-aminoethyl)amino]-
4-04-00-01558
N-Aminoethyl ethanolamine
2-((2-Aminoethyl)amino)ethanol
N-Aminoethylethanolamine
(2-Aminoethyl)ethanolamine
beta-Aminoethyl-beta-hydroxyethylamine
BRN 0506012
EINECS 203-867-5
Ethanolethylene diamine
Hydroxyethyl ethylenediamine
1-(2-(Hydroxyethyl)amino)-2-aminoethane
(beta-Hydroxyethyl)ethylenediamine
N-(beta-Hydroxyethyl)ethylenediamine
Monoethanolethylenediamine
N-Hydroxyethylethylenediamine
UNII-RC78W6NPXT
Chemical Function
Hardener
Chelating agent
No specific technical function
Regulatory Lists
CEDI
Indirect additives food contact (10/2018)
inert_ingredient; non_food_use; Pesticides
banned; Europe; Personal care
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3186403
Frequently Asked Questions
Is Aminoethylethanolamine allowed in the EU?
Aminoethylethanolamine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Aminoethylethanolamine do in cosmetics?
Aminoethylethanolamine functions as: Buffering. It is classified as a cosmetic ingredient in our database. CAS number: 111-41-1.
What is the NOAEL for Aminoethylethanolamine?
The NOAEL (No Observed Adverse Effect Level) for Aminoethylethanolamine is =50 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Aminoethylethanolamine used outside cosmetics?
Aminoethylethanolamine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Aminoethylethanolamine have different safety status in cosmetics vs industrial chemicals?
Aminoethylethanolamine is classified GHS Danger (H290, H314, H317, H318, H335, H360, H334, H373) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Aminoethylethanolamine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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