Is Eucalyptol Cosmetic safe in cosmetics?
Eucalyptol Cosmetic has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 5 toxicological study endpoint(s) are available in our database.
Eucalyptol Cosmetic
Also known as: Cineole, EINECS 207-431-5, FEMA No. 2465, NCI-C56575, 2-Oxa-1,3,3-trimethylbicyclo(2.2.2)octane (+4 more)
INCI: EUCALYPTOL
Eucalyptol Cosmetic (CAS 470-82-6) is a cosmetic cosmetic ingredient functioning as denaturant in SD Alcohol 38-B. NOAEL 33.3333 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted, max 1.3%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 470-82-6 →
Auto-generated CPSR Part A draft with source citations
Function
denaturant in SD Alcohol 38-B
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane
InChIKey
WEEGYLXZBRQIMU-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
EU Max Conc.
1.3%
US US Status
permitted
US Notes
No specific restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Eucalyptol Cosmetic.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Eucalyptol Cosmetic. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 200 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | =1000 mg/kg bw | oral: gavage | Rat | subchronic | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| NOAEL | =1000 mg/kg bw | oral: gavage | Rat | subchronic | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| NOAEL | =64.15 mg/kg bw/day | oral | Mouse | short-term | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Eucalyptol Cosmetic across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
5 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| NOAEL | =562.5 mg/kg-day | Mouse | oral | short-term | EFSA |
| LOAEL | =250 mg/kg-day | Rat | oral | - | ECHA IUCLID |
| LOAEL | =100 mg/kg-day | Rat | oral | subchronic | ECHA IUCLID |
| NOAEL | =64.15 mg/kg-day | Mouse | oral | short-term | ECHA IUCLID |
| LD50 | =2480 mg/kg | Rat | oral | - | ChemIDplus |
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 108 | 0 | 591 | 591 | non-sensitizer |
| HMT | - | 0 | 10368 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (4)
JECFA Number
1234
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
1,3,3-TRIMETHYL-2-OXABICYCLO[2.2.2]OCTANE | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/86 | FAS 52-JECFA 61/335
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
1,8-CINEOLE | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/86 | FAS 52-JECFA 61/335
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
EUCALYPTOL | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/86 | FAS 52-JECFA 61/335
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Humectant
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Eucalyptol Cosmetic.
Regulatory Flags
Allergen
epa_safer_alternative
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Eucalyptol Cosmetic by CAS number or substance name.
Studies
5
Lowest NOAEL
64.15
Highest NOAEL
1000
Units vary across source rows: mg/kg bw/day, mg/kg bw
ToxValDB_ECHA_IUCLID
COSMOS_DB
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
Known Synonyms
Cineole
EINECS 207-431-5
FEMA No. 2465
NCI-C56575
2-Oxa-1,3,3-trimethylbicyclo(2.2.2)octane
1,8-Oxido-p-menthane
Soledum
Eukalyptol
UNII-RV6J6604TK
Chemical Function
Fragrance
Humectant
Flavouring and nutrient
Regulatory Lists
Europe
active_ingredient; Europe; Pesticides
active_ingredient; Australia
active_ingredient; animal_products; Europe; pharmaceutical; residue
detected; Europe; Vehicle - car interior
air; detected; emissions; Europe; Vehicle - car interior - auto air freshener
air; Cleaning products and household care - air freshener; detected; emissions; Europe
detected; Europe; Personal care - sexual wellness
detected; Europe; Personal care - sexual wellness
detected; Europe; Personal care - liniment
Europe; Personal care - liniment
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
Canada; pharmaceutical
Canada; pharmaceutical
consumer_product
air; Cleaning products and household care - laundry and fabric treatment; detected; emissions
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
EUCALYPTOL
ChEMBL ID
CHEMBL485259
Max Phase
3
Adverse Event Associations
5
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
EUCALYPTOL
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Eucalyptol Cosmetic allowed in the EU?
Eucalyptol Cosmetic EU regulatory status: permitted. Maximum allowed concentration: 1.3%. This is based on EU Regulation 1223/2009 and its amendments.
What does Eucalyptol Cosmetic do in cosmetics?
Eucalyptol Cosmetic functions as: denaturant in SD Alcohol 38-B. It is classified as a cosmetic ingredient in our database. CAS number: 470-82-6.
What is the NOAEL for Eucalyptol Cosmetic?
The NOAEL (No Observed Adverse Effect Level) for Eucalyptol Cosmetic is 200 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 5 study endpoints are available. Source: COSMOS_DB.
Is Eucalyptol Cosmetic used outside cosmetics?
Eucalyptol Cosmetic also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Eucalyptol Cosmetic compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Skin Protecting
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Good
Chemical family
Denaturant, fragrance, masking agent
Cineole (Eucalyptol)
Moderate
Chemical family
Denaturant; fragrance
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