Is CINEOLE safe in cosmetics?
CINEOLE has a safety rating of "GOOD" in our database. EU status: permitted.
Good
Cosmetic Ingredient
CINEOLE
Also known as: 7-Oxabicyclo[2.2.1]heptane, 1-methyl-4-(1-methylethyl)-, 5-17-01-00273, BRN 0104974, EINECS 207-428-9, FEMA No. 3658 (+5 more)
CINEOLE (CAS 470-67-7) is a cosmetic cosmetic ingredient functioning as Skin Protecting. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 470-67-7 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Protecting
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane
InChIKey
RFFOTVCVTJUTAD-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 10800 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (1)
JECFA Evaluation
1-METHYL-4-(1-METHYLETHYL)-7-OXABICYCLO[2.2.1]HEPTANE | 2023 | No safety concern at current levels of intake when used as a flavouring agent | Considered for specifications only | TRS 1050-JECFA 96/46 | FAS 52-JECFA 61/335
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Humectant
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for CINEOLE.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to CINEOLE by CAS number or substance name.
Studies
3
Lowest NOAEL
600 mg/kg bw/day
Highest NOAEL
600 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
7-Oxabicyclo[2.2.1]heptane, 1-methyl-4-(1-methylethyl)-
5-17-01-00273
BRN 0104974
EINECS 207-428-9
FEMA No. 3658
Isocineole
1-Isopropyl-4-methyl-7-oxabicyclo(2.2.1)heptane
7-Oxabicyclo(2.2.1)heptane, 1-isopropyl-4-methyl-
UNII-B55JTU839B
1,4-Epoxy-p-menthane
Chemical Function
Humectant
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
inert_ingredient; non_food_use; Pesticides
air; Cleaning products and household care - laundry and fabric treatment; detected; emissions
air; detected; emissions; Personal care
air; Cleaning products and household care; detected; emissions
detected; Europe; Vehicle - car interior
air; detected; emissions; Europe; Vehicle - car interior
Australian Status
AICIS status: listed
Frequently Asked Questions
Is CINEOLE allowed in the EU?
CINEOLE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CINEOLE do in cosmetics?
CINEOLE functions as: Skin Protecting. It is classified as a cosmetic ingredient in our database. CAS number: 470-67-7.
Compliance Tools
Check CINEOLE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Cineole (1,8-Cineole / Eucalyptol)
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Chemical family
Denaturant, fragrance, masking agent
Cineole (Eucalyptol)
Moderate
Chemical family
Denaturant; fragrance
Eucalyptol Cosmetic
Good
Chemical family
denaturant in SD Alcohol 38-B
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