Is Ethyl Phenethyl Acetal safe in cosmetics?
Ethyl Phenethyl Acetal has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Ethyl Phenethyl Acetal
Also known as: Benzene, [2-(1-ethoxyethoxy)ethyl]-, 3-06-00-01708, Acetaldehyde, ethyl phenethyl acetal, Acetaldehyde ethyl phenylethyl acetal, Acetaldehyde ethyl 2-phenylethyl acetal (+6 more)
INCI: ETHYL PHENETHYL ACETAL
Ethyl Phenethyl Acetal (CAS 2556-10-7) is a cosmetic cosmetic ingredient functioning as Fragrance / Perfuming. NOAEL 377 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 2556-10-7 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance / Perfuming
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-(1-ethoxyethoxy)ethylbenzene
InChIKey
QQDGMPOYFGNLMT-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — not restricted under 21 CFR; FEMA/GRAS status available for food use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethyl Phenethyl Acetal.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Ethyl Phenethyl Acetal across SCCS product categories, with measured dermal absorption where available.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
1350 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [71] Kligman AM (1975): Report to RIFM, 15 January, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 1350 | - | - |
| HMT | - | 0 | 3375 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Ethyl Phenethyl Acetal.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
Known Synonyms
Benzene, [2-(1-ethoxyethoxy)ethyl]-
3-06-00-01708
Acetaldehyde, ethyl phenethyl acetal
Acetaldehyde ethyl phenylethyl acetal
Acetaldehyde ethyl 2-phenylethyl acetal
Benzene, 2-(1'-(ethoxy)ethoxy)ethyl-
BRN 2364509
EINECS 219-868-9
Ethane, 1-ethoxy-1-(2-phenylethoxy)-
Hyacinth Body
UNII-Z7156Q4C3R
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
consumer_product
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Ethyl Phenethyl Acetal allowed in the EU?
Ethyl Phenethyl Acetal EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethyl Phenethyl Acetal do in cosmetics?
Ethyl Phenethyl Acetal functions as: Fragrance / Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 2556-10-7.
Is Ethyl Phenethyl Acetal used outside cosmetics?
Ethyl Phenethyl Acetal also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ethyl Phenethyl Acetal compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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