What is the NOAEL for [2-(1-Ethoxyethoxy)ethyl]benzene?
[2-(1-Ethoxyethoxy)ethyl]benzene has 12 NOAEL studies in the database. The lowest reported value is 18.5 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
[2-(1-Ethoxyethoxy)ethyl]benzene
Also known as: Benzene, [2-(1-ethoxyethoxy)ethyl]-, Ethyl phenethyl acetal, 3-06-00-01708, Acetaldehyde, ethyl phenethyl acetal, Acetaldehyde ethyl phenylethyl acetal (+7 more)
CAS 2556-10-7
[2-(1-Ethoxyethoxy)ethyl]benzene (CAS 2556-10-7) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
[2-(1-Ethoxyethoxy)ethyl]benzene
CAS Number
2556-10-7
DTXSID
DTXSID6051930
Molecular Formula
C12H18O2
InChI Key
QQDGMPOYFGNLMT-UHFFFAOYSA-N
Monoisotopic Mass
194.13068
Synonyms
Benzene, [2-(1-ethoxyethoxy)ethyl]-Ethyl phenethyl acetal3-06-00-01708Acetaldehyde, ethyl phenethyl acetalAcetaldehyde ethyl phenylethyl acetalAcetaldehyde ethyl 2-phenylethyl acetalBenzene, 2-(1'-(ethoxy)ethoxy)ethyl-BRN 2364509EINECS 219-868-9Ethane, 1-ethoxy-1-(2-phenylethoxy)-Hyacinth BodyUNII-Z7156Q4C3R
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
7 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =18.5 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| Z7156Q4C3R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Z7156Q4C3R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Z7156Q4C3R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Z7156Q4C3R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1350 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 3375 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >=377 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=480 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | [2-(1-ethoxyethoxy)ethyl]benzene | 219-868-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include [2-(1-Ethoxyethoxy)ethyl]benzene?
[2-(1-Ethoxyethoxy)ethyl]benzene appears on 3 regulatory/inventory lists including Europe, IFRA Transparency, consumer_product. Source: EPA CPDat.
Is [2-(1-Ethoxyethoxy)ethyl]benzene used in cosmetics?
Yes, [2-(1-Ethoxyethoxy)ethyl]benzene is also indexed as a cosmetic ingredient under the name Ethyl Phenethyl Acetal. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for [2-(1-Ethoxyethoxy)ethyl]benzene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is [2-(1-Ethoxyethoxy)ethyl]benzene used outside industrial chemicals?
[2-(1-Ethoxyethoxy)ethyl]benzene also appears in cosmetics, cannabis databases.