Is Acetaldehyde Diethyl Acetal safe in cosmetics?
Acetaldehyde Diethyl Acetal has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Acetaldehyde Diethyl Acetal
Also known as: Acetaldehyde, diethyl acetal, NSC 7624, UN 1088 (DOT), EC No.: 203-310-6, BRN 1098310 (+11 more)
INCI: ACETALDEHYDE DIETHYL ACETAL
Acetaldehyde Diethyl Acetal (CAS 105-57-7) is a cosmetic cosmetic ingredient functioning as Fragrance / Perfuming. Reported NOAEL =120 mg/kg bw/day in Rat (EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 105-57-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Acetaldehyde Diethyl Acetal is classified GHS Danger (H225, H315, H319) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance / Perfuming
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not restricted by FDA; FEMA GRAS #2002
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acetaldehyde Diethyl Acetal.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Acetaldehyde Diethyl Acetal. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =120 mg/kg bw/day | oral: drinking water | Rat | subchronic | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. Exposure could cause lowering of consciousness.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
FlammableHarmful / Irritant
Hazard Class and Category
Flam. Liq. 2; Skin Irrit. 2; Eye Irrit. 2
Hazard Statements
- H225 Highly flammable liquid and vapour
- H315 Causes skin irritation
- H319 Causes serious eye irritation
Inserted via ATP: CLP00
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 6480 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Acetaldehyde Diethyl Acetal.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Acetaldehyde Diethyl Acetal by CAS number or substance name.
Studies
1
Lowest NOAEL
120 mg/kg bw/day
Highest NOAEL
120 mg/kg bw/day
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
Known Synonyms
Acetaldehyde, diethyl acetal
NSC 7624
UN 1088 (DOT)
EC No.: 203-310-6
BRN 1098310
EINECS 203-310-6
Ethylidenediethyl ether
FEMA No. 2002
1,1-Diaethoxy-aethan
1,1-Diethoxy-ethaan
1,1-Dietossietano
Acetaal
Acetal diethylique
Acetale
Diaethylacetal
UNII-5G14F9E2HB
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
air; detected; emissions; Personal care
detected; Europe; Personal care - body adhesive
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
detected; Europe; Other direct contact consumer goods
air; detected; emissions; Europe; Other direct contact consumer goods
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1338583
Frequently Asked Questions
Is Acetaldehyde Diethyl Acetal allowed in the EU?
Acetaldehyde Diethyl Acetal EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acetaldehyde Diethyl Acetal do in cosmetics?
Acetaldehyde Diethyl Acetal functions as: Fragrance / Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 105-57-7.
What is the NOAEL for Acetaldehyde Diethyl Acetal?
The NOAEL (No Observed Adverse Effect Level) for Acetaldehyde Diethyl Acetal is =120 mg/kg bw/day based on a subchronic study via oral: drinking water route in Rat. Source: EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx.
Is Acetaldehyde Diethyl Acetal used outside cosmetics?
Acetaldehyde Diethyl Acetal also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Acetaldehyde Diethyl Acetal have different safety status in cosmetics vs industrial chemicals?
Acetaldehyde Diethyl Acetal is classified GHS Danger (H225, H315, H319) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
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Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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