Is Dodecanenitrile safe in cosmetics?
Dodecanenitrile has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Dodecanenitrile
Also known as: BRN 0970348, 1-Cyanoundecane, Decylacetonitrile, Dodecane nitrile, Dodecanonitrile (+7 more)
INCI: DODECANENITRILE
Dodecanenitrile (CAS 2437-25-4) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. NOAEL 50 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 2437-25-4 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
dodecanenitrile
InChIKey
VXCUURYYWGCLIH-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no 21 CFR restriction; RIFM-assessed for fragrance use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dodecanenitrile.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Dodecanenitrile. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =250 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Dodecanenitrile across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | - | 0 | 581 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Dodecanenitrile.
Regulatory Flags
fragrance-component
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Dodecanenitrile by CAS number or substance name.
Studies
13
Lowest NOAEL
250 mg/kg bw/day
Highest NOAEL
852.5 mg/kg bw/day
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
BRN 0970348
1-Cyanoundecane
Decylacetonitrile
Dodecane nitrile
Dodecanonitrile
EINECS 219-440-1
Lauric acid nitrile
Lauric nitrile
Lauronitrile
NSC 1804
Undecyl cyanide
UNII-TL45I6761P
Chemical Function
Fragrance
Regulatory Lists
IFRA Transparency
consumer_product
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Dodecanenitrile allowed in the EU?
Dodecanenitrile EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dodecanenitrile do in cosmetics?
Dodecanenitrile functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 2437-25-4.
What is the NOAEL for Dodecanenitrile?
The NOAEL (No Observed Adverse Effect Level) for Dodecanenitrile is =250 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Dodecanenitrile used outside cosmetics?
Dodecanenitrile also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dodecanenitrile compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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