NOAEL Studies Cosmetic Ingredient

Dodecanenitrile NOAEL Studies

INCI: DODECANENITRILE

CAS: 2437-25-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 15 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 250 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=83caf48a-86fc-4087-8a45-8bf49b5ebe59.i6z; document=51674d88-429a-48dd-bb47-2cf19e699e0a_83caf48a-86fc-4087-8a45-8bf49b5ebe59.i6d; document_key=51674d88-429a-48dd-bb47-2cf19e699e0a/83caf48a-86fc-4087-8a45-8bf49b5ebe59; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2007; ReportDate=2007-06-15; basis=body weight and weight gain; key_result=false; entry_uuid=1cec6146-9d8d-40b3-9ed0-83b702af0975
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 250 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=83caf48a-86fc-4087-8a45-8bf49b5ebe59.i6z; document=51674d88-429a-48dd-bb47-2cf19e699e0a_83caf48a-86fc-4087-8a45-8bf49b5ebe59.i6d; document_key=51674d88-429a-48dd-bb47-2cf19e699e0a/83caf48a-86fc-4087-8a45-8bf49b5ebe59; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2007; ReportDate=2007-06-15; basis=body weight and weight gain; key_result=false; entry_uuid=1cec6146-9d8d-40b3-9ed0-83b702af0975
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 500 mg/kg bw/day rat oral: gavage - one-generation reproductive toxicity dossier=bff7f41a-6e5a-4be6-a72f-3e4a202f48a6.i6z; document=68009205-c92c-4057-897f-69857d2d2c0b_bff7f41a-6e5a-4be6-a72f-3e4a202f48a6.i6d; document_key=68009205-c92c-4057-897f-69857d2d2c0b/bff7f41a-6e5a-4be6-a72f-3e4a202f48a6; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2017; basis=clinical signs; key_result=false; entry_uuid=db7b2fcd-1fa8-4e5f-a2b5-78485edfed54
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 567.036865234 mg/kg bw/day rat oral: gavage - repeated dose toxicity: oral dossier=bff7f41a-6e5a-4be6-a72f-3e4a202f48a6.i6z; document=ef3c7ad3-3e09-48b9-8bf6-83bb1c76224f_bff7f41a-6e5a-4be6-a72f-3e4a202f48a6.i6d; document_key=ef3c7ad3-3e09-48b9-8bf6-83bb1c76224f/bff7f41a-6e5a-4be6-a72f-3e4a202f48a6; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2017; basis=other:; key_result=true; entry_uuid=2b0321bf-c74f-4cdd-a0a2-fa2f1c55debc
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 852.5 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=bff7f41a-6e5a-4be6-a72f-3e4a202f48a6.i6z; document=f5416685-7f1b-4228-997b-54ad3f382450_bff7f41a-6e5a-4be6-a72f-3e4a202f48a6.i6d; document_key=f5416685-7f1b-4228-997b-54ad3f382450/bff7f41a-6e5a-4be6-a72f-3e4a202f48a6; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2017; basis=reproductive performance; key_result=true; entry_uuid=b6bace4a-b7a1-4221-84bc-953e5ac5b489
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 500 mg/kg bw/day rat oral: gavage - one-generation reproductive toxicity dossier=bff7f41a-6e5a-4be6-a72f-3e4a202f48a6.i6z; document=68009205-c92c-4057-897f-69857d2d2c0b_bff7f41a-6e5a-4be6-a72f-3e4a202f48a6.i6d; document_key=68009205-c92c-4057-897f-69857d2d2c0b/bff7f41a-6e5a-4be6-a72f-3e4a202f48a6; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2017; basis=clinical signs; key_result=false; entry_uuid=db7b2fcd-1fa8-4e5f-a2b5-78485edfed54
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 567.036865234 mg/kg bw/day rat oral: gavage - repeated dose toxicity: oral dossier=bff7f41a-6e5a-4be6-a72f-3e4a202f48a6.i6z; document=ef3c7ad3-3e09-48b9-8bf6-83bb1c76224f_bff7f41a-6e5a-4be6-a72f-3e4a202f48a6.i6d; document_key=ef3c7ad3-3e09-48b9-8bf6-83bb1c76224f/bff7f41a-6e5a-4be6-a72f-3e4a202f48a6; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2017; basis=other:; key_result=true; entry_uuid=2b0321bf-c74f-4cdd-a0a2-fa2f1c55debc
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 852.5 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=bff7f41a-6e5a-4be6-a72f-3e4a202f48a6.i6z; document=f5416685-7f1b-4228-997b-54ad3f382450_bff7f41a-6e5a-4be6-a72f-3e4a202f48a6.i6d; document_key=f5416685-7f1b-4228-997b-54ad3f382450/bff7f41a-6e5a-4be6-a72f-3e4a202f48a6; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2017; basis=reproductive performance; key_result=true; entry_uuid=b6bace4a-b7a1-4221-84bc-953e5ac5b489
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 250 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=83caf48a-86fc-4087-8a45-8bf49b5ebe59.i6z; document=51674d88-429a-48dd-bb47-2cf19e699e0a_83caf48a-86fc-4087-8a45-8bf49b5ebe59.i6d; document_key=51674d88-429a-48dd-bb47-2cf19e699e0a/83caf48a-86fc-4087-8a45-8bf49b5ebe59; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2007; ReportDate=2007-06-15; basis=body weight and weight gain; key_result=false; entry_uuid=1cec6146-9d8d-40b3-9ed0-83b702af0975
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 500 mg/kg bw/day rat oral: gavage - one-generation reproductive toxicity dossier=bff7f41a-6e5a-4be6-a72f-3e4a202f48a6.i6z; document=68009205-c92c-4057-897f-69857d2d2c0b_bff7f41a-6e5a-4be6-a72f-3e4a202f48a6.i6d; document_key=68009205-c92c-4057-897f-69857d2d2c0b/bff7f41a-6e5a-4be6-a72f-3e4a202f48a6; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2017; basis=clinical signs; key_result=false; entry_uuid=db7b2fcd-1fa8-4e5f-a2b5-78485edfed54
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 567.036865234 mg/kg bw/day rat oral: gavage - repeated dose toxicity: oral dossier=bff7f41a-6e5a-4be6-a72f-3e4a202f48a6.i6z; document=ef3c7ad3-3e09-48b9-8bf6-83bb1c76224f_bff7f41a-6e5a-4be6-a72f-3e4a202f48a6.i6d; document_key=ef3c7ad3-3e09-48b9-8bf6-83bb1c76224f/bff7f41a-6e5a-4be6-a72f-3e4a202f48a6; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2017; basis=other:; key_result=true; entry_uuid=2b0321bf-c74f-4cdd-a0a2-fa2f1c55debc
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 852.5 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=bff7f41a-6e5a-4be6-a72f-3e4a202f48a6.i6z; document=f5416685-7f1b-4228-997b-54ad3f382450_bff7f41a-6e5a-4be6-a72f-3e4a202f48a6.i6d; document_key=f5416685-7f1b-4228-997b-54ad3f382450/bff7f41a-6e5a-4be6-a72f-3e4a202f48a6; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2017; basis=reproductive performance; key_result=true; entry_uuid=b6bace4a-b7a1-4221-84bc-953e5ac5b489
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOEL 50 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=83caf48a-86fc-4087-8a45-8bf49b5ebe59.i6z; document=51674d88-429a-48dd-bb47-2cf19e699e0a_83caf48a-86fc-4087-8a45-8bf49b5ebe59.i6d; document_key=51674d88-429a-48dd-bb47-2cf19e699e0a/83caf48a-86fc-4087-8a45-8bf49b5ebe59; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2007; ReportDate=2007-06-15; basis=other:; key_result=false; entry_uuid=6ced4c55-49ae-420e-9143-29df972e5971
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOEL 50 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=83caf48a-86fc-4087-8a45-8bf49b5ebe59.i6z; document=51674d88-429a-48dd-bb47-2cf19e699e0a_83caf48a-86fc-4087-8a45-8bf49b5ebe59.i6d; document_key=51674d88-429a-48dd-bb47-2cf19e699e0a/83caf48a-86fc-4087-8a45-8bf49b5ebe59; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2007; ReportDate=2007-06-15; basis=other:; key_result=false; entry_uuid=6ced4c55-49ae-420e-9143-29df972e5971
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOEL 50 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=83caf48a-86fc-4087-8a45-8bf49b5ebe59.i6z; document=51674d88-429a-48dd-bb47-2cf19e699e0a_83caf48a-86fc-4087-8a45-8bf49b5ebe59.i6d; document_key=51674d88-429a-48dd-bb47-2cf19e699e0a/83caf48a-86fc-4087-8a45-8bf49b5ebe59; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2007; ReportDate=2007-06-15; basis=other:; key_result=false; entry_uuid=6ced4c55-49ae-420e-9143-29df972e5971
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=6241; Record_ID=skin_sensitization_invivo_1432; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.75; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1022188; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1965; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2018; 29325807; 10.1016/j.fct.2018.01.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1022188
NTP_ICE_skin_sensitization Induction dose per skin area 581 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=6239; Record_ID=skin_sensitization_invivo_1432; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.75; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1022188; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=581; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1965; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2018; 29325807; 10.1016/j.fct.2018.01.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1022188
NTP_ICE_skin_sensitization Relative reliability score 4 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=6245; Record_ID=skin_sensitization_invivo_1432; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.75; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1022188; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=4; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=RIFM 1965; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2018; 29325807; 10.1016/j.fct.2018.01.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1022188
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =250 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaad2e4b0a7c65d1b799b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2083/7/9/2?documentUUID=83caf48a-86fc-4087-8a45-8bf49b5ebe59; TOXICOLOGICAL_EFFECT=F1: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15859156:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_396a9f0061ad72231dde5246369d9240
ToxValDB_ECHA_IUCLID NOEL =50 mg/kg bw/day Rat oral short-term; 14 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7caf2e4b0a7c65d22420e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2083/7/6/2?documentUUID=83caf48a-86fc-4087-8a45-8bf49b5ebe59; STUDY_GROUP=ECHA IUCLID:15829989:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4b07a8a9283132d9ece4b69ab32c21b1
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =14 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632931:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fbf0aa1fb2cfc7f39412be8e0ce1595f
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier TL45I6761P UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H23N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"TL45I6761P"}
openFDA substances FDA UNII substance identifier TL45I6761P UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H23N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"TL45I6761P"}
openFDA substances FDA UNII substance identifier TL45I6761P UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H23N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"TL45I6761P"}
openFDA substances FDA UNII substance identifier TL45I6761P UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H23N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"TL45I6761P"}