Is Dimethyl Maleate safe in cosmetics?
Dimethyl Maleate has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Dimethyl Maleate
Also known as: 2-Butenedioic acid (2Z)-, dimethyl ester, 4-02-00-02204, BRN 0471705, EINECS 210-848-5, NSC 5161 (+4 more)
INCI: DIMETHYL MALEATE
Dimethyl Maleate (CAS 624-48-6) is a cosmetic cosmetic ingredient functioning as YELLOW. Reported NOAEL =200 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 624-48-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Dimethyl Maleate is classified GHS Danger (H302, H314, H317, H319, H335, H311, H320, H401) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Chemistry & Identifiers
IUPAC Name
dimethyl (Z)-but-2-enedioate
InChIKey
LDCRTTXIJACKKU-ARJAWSKDSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not prohibited by CFR, but not typically listed for cosmetic use. Dialkyl malates reviewed by CIR (diisostearyl malate group), but dimethyl maleate itself was not included in the safety assessment.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dimethyl Maleate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Dimethyl Maleate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =200 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Plasticizer
Softener and conditioner
Solvent
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Dimethyl Maleate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Dimethyl Maleate by CAS number or substance name.
Studies
4
Lowest NOAEL
200 mg/kg bw/day
Highest NOAEL
200 mg/kg bw/day
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
2-Butenedioic acid (2Z)-, dimethyl ester
4-02-00-02204
BRN 0471705
EINECS 210-848-5
NSC 5161
Dimethylester kyseliny maleinove
UNII-K39366X5N0
2-Butenedioic acid, dimethyl ester, (Z)-
Methyl maleate
Chemical Function
Solvent
Softener and conditioner
Plasticizer
Regulatory Lists
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DIMETHYL MALEATE
ChEMBL ID
CHEMBL2259700
Frequently Asked Questions
Is Dimethyl Maleate allowed in the EU?
Dimethyl Maleate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethyl Maleate do in cosmetics?
Dimethyl Maleate functions as: YELLOW. It is classified as a cosmetic ingredient in our database. CAS number: 624-48-6.
What is the NOAEL for Dimethyl Maleate?
The NOAEL (No Observed Adverse Effect Level) for Dimethyl Maleate is =200 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Dimethyl Maleate used outside cosmetics?
Dimethyl Maleate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Dimethyl Maleate have different safety status in cosmetics vs industrial chemicals?
Dimethyl Maleate is classified GHS Danger (H302, H314, H317, H319, H335, H311, H320, H401) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Dimethyl Maleate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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