NOAEL Studies Cosmetic Ingredient

Dimethyl Maleate NOAEL Studies

INCI: DIMETHYL MALEATE

CAS: 624-48-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =1410 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_8568; row=7777; data_type=In Vivo; mixture=Chemical; chemical_name=Dimethyl maleate; preferred_name=Dimethyl maleate; dtxsid=DTXSID4040765; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4040765; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =1909 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_8570; row=7778; data_type=In Vivo; mixture=Chemical; chemical_name=Dimethyl maleate; preferred_name=Dimethyl maleate; dtxsid=DTXSID4040765; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4040765; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LEL >1500 mg/m3 Mouse inhalation - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1267/7/3/3?documentUUID=d358136b-2af8-4d3d-8351-00a8519511c9; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID:15796343:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_91c9860bdadf34d26880c7c8370563dd
ToxValDB_ECHA_IUCLID NOAEL =200 mg/kg bw/day Rat oral short-term; 14 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb78e4b0a7c65d2264d7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1267/7/6/2?documentUUID=d358136b-2af8-4d3d-8351-00a8519511c9; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID:15832804:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e6e550d1daf5e6053cd13a8e71fdb894
ToxValDB_ECHA_IUCLID NOEL =60 mg/kg bw/day Rat dermal short-term; 28 days short-term QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61da4e4b096bca8776860; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1267/7/6/4?documentUUID=e0b5ee0e-a0a3-4a36-ae4d-ee4787b2f2c4; STUDY_GROUP=ECHA IUCLID:15826251:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_aad76b242d0bcdecf447be8671328736
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =19.4 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631416:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d771c50638cebe95064812da0b6fb82e
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier K39366X5N0 UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H8O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"K39366X5N0"}
openFDA substances FDA UNII substance identifier K39366X5N0 UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H8O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"K39366X5N0"}
openFDA substances FDA UNII substance identifier K39366X5N0 UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H8O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"K39366X5N0"}
openFDA substances FDA UNII substance identifier K39366X5N0 UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H8O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"K39366X5N0"}