What is the NOAEL for Dimethyl maleate?
Dimethyl maleate has 10 NOAEL studies in the database. The lowest reported value is 19.4 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dimethyl maleate
Also known as: 2-Butenedioic acid (2Z)-, dimethyl ester, 4-02-00-02204, BRN 0471705, EINECS 210-848-5, NSC 5161 (+4 more)
CAS 624-48-6
Dimethyl maleate (CAS 624-48-6) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Dimethyl maleate is classified GHS Danger (H302, H314, H317, H319, H335, H311, H320, H401) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
Dimethyl maleate
CAS Number
624-48-6
DTXSID
DTXSID4040765
Molecular Formula
C6H8O4
InChI Key
LDCRTTXIJACKKU-ARJAWSKDSA-N
Monoisotopic Mass
144.042259
Synonyms
2-Butenedioic acid (2Z)-, dimethyl ester4-02-00-02204BRN 0471705EINECS 210-848-5NSC 5161Dimethylester kyseliny maleinoveUNII-K39366X5N02-Butenedioic acid, dimethyl ester, (Z)-Methyl maleate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
SolventSoftener and conditionerPlasticizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =19.4 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| K39366X5N0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K39366X5N0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K39366X5N0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K39366X5N0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1410 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1909 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >1500 | mg/m3 | LEL | inhalation | Mouse | ToxValDB_ECHA_IUCLID |
| =200 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =60 | mg/kg bw/day | NOEL | dermal | Rat | ToxValDB_ECHA_IUCLID |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dimethyl maleate | 210-848-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
DIMETHYL MALEATE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Frequently Asked Questions
What regulatory lists include Dimethyl maleate?
Dimethyl maleate appears on 1 regulatory/inventory list including Indirect additives food contact (10/2018). Source: EPA CPDat.
Is Dimethyl maleate used in cosmetics?
Yes, Dimethyl maleate is also indexed as a cosmetic ingredient under the name Dimethyl Maleate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dimethyl maleate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Dimethyl maleate have different safety status in cosmetics vs industrial chemicals?
Dimethyl maleate is classified GHS Danger (H302, H314, H317, H319, H335, H311, H320, H401) in the chemicals database but is allowed in EU cosmetics.
Is Dimethyl maleate used outside industrial chemicals?
Dimethyl maleate also appears in cosmetics, pharmaceutical databases.