Is Dihydroxybiphenyl safe in cosmetics?
Dihydroxybiphenyl has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted.
Poor
Cosmetic Ingredient
Dihydroxybiphenyl
Also known as: [1,1'-Biphenyl]-4,4'-diol, 4-(4-Hydroxyphenyl)phenol, B 0464, BPL, BPL (phenol) (+9 more)
INCI: DIHYDROXYBIPHENYL
Dihydroxybiphenyl (CAS 92-88-6) is a cosmetic cosmetic ingredient functioning as Antioxidant / stabilizer (primarily industrial; rare cosmetic use). NOAEL 125 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 92-88-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Dihydroxybiphenyl is classified GHS CMR hazard (H312, H315, H317, H319, H335, H411, H412, H341) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antioxidant / stabilizer (primarily industrial; rare cosmetic use)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
4-(4-hydroxyphenyl)phenol
InChIKey
VCCBEIPGXKNHFW-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically restricted under 21 CFR Parts 700–740; permitted by default
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dihydroxybiphenyl.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Dihydroxybiphenyl across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Bleaching agent
Humectant
Expert Verdict
Expert safety assessment and concern-level summary for Dihydroxybiphenyl.
Known Synonyms
[1,1'-Biphenyl]-4,4'-diol
4-(4-Hydroxyphenyl)phenol
B 0464
BPL
BPL (phenol)
DOD
4-06-00-06651
BRN 1908886
4,4'-Dioxydiphenol
EINECS 202-200-5
para,para'-Biphenol
Phenol p-(p-hydroxyphenyl)-
UNII-R8994A0904
4,4'-dioxydiphenyl
Chemical Function
Humectant
Bleaching agent
Regulatory Lists
drinking_water; Europe; manufacturing; plastic_additive
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL76398
Frequently Asked Questions
Is Dihydroxybiphenyl allowed in the EU?
Dihydroxybiphenyl EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dihydroxybiphenyl do in cosmetics?
Dihydroxybiphenyl functions as: Antioxidant / stabilizer (primarily industrial; rare cosmetic use). It is classified as a cosmetic ingredient in our database. CAS number: 92-88-6.
Is Dihydroxybiphenyl used outside cosmetics?
Dihydroxybiphenyl also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Dihydroxybiphenyl have different safety status in cosmetics vs industrial chemicals?
Dihydroxybiphenyl is classified GHS CMR hazard (H312, H315, H317, H319, H335, H411, H412, H341) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Dihydroxybiphenyl compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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