What is the NOAEL for 4,4'-Biphenyldiol?
4,4'-Biphenyldiol has 7 NOAEL studies in the database. The lowest reported value is 5.28 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
4,4'-Biphenyldiol
Also known as: [1,1'-Biphenyl]-4,4'-diol, 4-(4-Hydroxyphenyl)phenol, B 0464, BPL, BPL (phenol) (+9 more)
CAS 92-88-6
4,4'-Biphenyldiol (CAS 92-88-6) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
4,4'-Biphenyldiol is classified GHS CMR hazard (H312, H315, H317, H319, H335, H411, H412, H341) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
20 fields
Name
4,4'-Biphenyldiol
CAS Number
92-88-6
DTXSID
DTXSID1029120
Molecular Formula
C12H10O2
InChI Key
VCCBEIPGXKNHFW-UHFFFAOYSA-N
Monoisotopic Mass
186.06808
Synonyms
[1,1'-Biphenyl]-4,4'-diol4-(4-Hydroxyphenyl)phenolB 0464BPLBPL (phenol)DOD4-06-00-06651BRN 19088864,4'-DioxydiphenolEINECS 202-200-5para,para'-BiphenolPhenol p-(p-hydroxyphenyl)-
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
HumectantBleaching agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =5.28 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| R8994A0904 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R8994A0904 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R8994A0904 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R8994A0904 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =4920 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Biphenyl-4,4'-diol | 202-200-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL76398
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Frequently Asked Questions
What regulatory lists include 4,4'-Biphenyldiol?
4,4'-Biphenyldiol appears on 1 regulatory/inventory list including drinking_water; Europe; manufacturing; plastic_additive. Source: EPA CPDat.
Is 4,4'-Biphenyldiol used in cosmetics?
Yes, 4,4'-Biphenyldiol is also indexed as a cosmetic ingredient under the name Dihydroxybiphenyl. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4,4'-Biphenyldiol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 4,4'-Biphenyldiol have different safety status in cosmetics vs industrial chemicals?
4,4'-Biphenyldiol is classified GHS CMR hazard (H312, H315, H317, H319, H335, H411, H412, H341) in the chemicals database but is allowed in EU cosmetics.
Is 4,4'-Biphenyldiol used outside industrial chemicals?
4,4'-Biphenyldiol also appears in cosmetics, pharmaceutical databases.