What is the NOAEL for (+)-Taxifolin?
(+)-Taxifolin has 5 NOAEL studies in the database. The lowest reported value is 9SOB9E3987 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
(+)-Taxifolin
Also known as: (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one, (2R,3R)-Dihydroquercetin, 5-18-05-00451, 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, BRN 0093548 (+10 more)
CAS 480-18-2
(+)-Taxifolin (CAS 480-18-2) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
21 fields
Name
(+)-Taxifolin
CAS Number
480-18-2
DTXSID
DTXSID8022450
Molecular Formula
C15H12O7
InChI Key
CXQWRCVTCMQVQX-LSDHHAIUSA-N
Monoisotopic Mass
304.058303
Synonyms
(2R,3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one(2R,3R)-Dihydroquercetin5-18-05-004514H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-BRN 0093548Catechin hydrateEINECS 207-543-4Flavone, 2,3-dihydro-3,3',4',5,7-pentahydroxy-3,3',4',5,7-PentahydroxyflavanoneQuercetin, dihydro-UNII-9SOB9E3987Lavitol
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Antioxidant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 9SOB9E3987 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9SOB9E3987 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9SOB9E3987 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9SOB9E3987 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1500 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | (2R-trans)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyrone | 207-543-4 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
(+)-TAXIFOLIN
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
9
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
FDA GRAS: At the notifier's request, FDA ceased to evaluate this notice
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include (+)-Taxifolin?
(+)-Taxifolin appears on 1 regulatory/inventory list including Canada; pharmaceutical. Source: EPA CPDat.
Is (+)-Taxifolin used in cosmetics?
Yes, (+)-Taxifolin is also indexed as a cosmetic ingredient under the name Dihydroquercetin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for (+)-Taxifolin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is (+)-Taxifolin used outside industrial chemicals?
(+)-Taxifolin also appears in cosmetics, pharmaceutical, food safety, cannabis databases.