Is Dihydrocitronellol safe in cosmetics?
Dihydrocitronellol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Dihydrocitronellol
Also known as: 1-Octanol, 3,7-dimethyl-, 1-01-00-00214, BRN 1719638, Citronellol, dihydro-, Dimethyl octanol (+13 more)
INCI: DIHYDROCITRONELLOL
Dihydrocitronellol (CAS 106-21-8) is a cosmetic cosmetic ingredient functioning as Fragrance. NOAEL 150 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 106-21-8 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3,7-dimethyloctan-1-ol
InChIKey
PRNCMAKCNVRZFX-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no 21 CFR restriction; RIFM assessed as part of acyclic terpene alcohol group
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dihydrocitronellol.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Dihydrocitronellol across SCCS product categories, with measured dermal absorption where available.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
5184 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [180] Kligman AM (1973): Report to RIFM, 12 February, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 5184 | - | - |
| HMT | - | 0 | 5184 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
272
Source: WHO/JECFA
JECFA Evaluation
3,7-DIMETHYL-1-OCTANOL | 2002 | No safety concern at current levels of intake when used as a flavouring agent | Secondary components do not raise a safety concern | TRS 913-JECFA 59/111 | FAS 40-JECFA 49/189 (1997)
Source: WHO/JECFA
JECFA Evaluation
TETRAHYDROGERANIOL | 2002 | No safety concern at current levels of intake when used as a flavouring agent | Secondary components do not raise a safety concern | TRS 913-JECFA 59/111 | FAS 40-JECFA 49/189 (1997)
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Dihydrocitronellol.
Regulatory Flags
potential-allergen
fragrance-component
epa_safer_alternative
ifra_fragrance
fda_food_additive
Known Synonyms
1-Octanol, 3,7-dimethyl-
1-01-00-00214
BRN 1719638
Citronellol, dihydro-
Dimethyl octanol
Dimethyloctanol
2,6-Dimethyl-8-octanol
3,7-Dimethyl-1-octanol
EINECS 203-374-5
FEMA No. 2391
Geraniol, perhydro-
Geraniol tetrahydride
Geraniol, tetrahydro-
NSC 18917
Pelargol
Perhydrogeraniol
Tetrahydrogeraniol
UNII-DPY9K1927C
Chemical Function
Fragrance
Deodorizer
Flavouring and nutrient
Regulatory Lists
air; detected; emissions; Europe; Other direct contact consumer goods
detected; Europe; Other direct contact consumer goods
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
detected; Europe; Other direct contact consumer goods
detected; Europe; Other direct contact consumer goods
Europe
SCIL (9/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
3,7-DIMETHYL-1-OCTANOL
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Dihydrocitronellol allowed in the EU?
Dihydrocitronellol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dihydrocitronellol do in cosmetics?
Dihydrocitronellol functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 106-21-8.
Is Dihydrocitronellol used outside cosmetics?
Dihydrocitronellol also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dihydrocitronellol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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