What is the NOAEL for 3,7-Dimethyloctan-1-ol?
3,7-Dimethyloctan-1-ol has 9 NOAEL studies in the database. The lowest reported value is 5.3 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
3,7-Dimethyloctan-1-ol
Also known as: 1-Octanol, 3,7-dimethyl-, 1-01-00-00214, BRN 1719638, Citronellol, dihydro-, Dihydrocitronellol (+14 more)
CAS 106-21-8
3,7-Dimethyloctan-1-ol (CAS 106-21-8) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
9
SOURCE
Chemical inventory jurisdictions
Regulatory lists
8
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
3,7-Dimethyloctan-1-ol
CAS Number
106-21-8
DTXSID
DTXSID5044360
Molecular Formula
C10H22O
InChI Key
PRNCMAKCNVRZFX-UHFFFAOYSA-N
Monoisotopic Mass
158.167065
Synonyms
1-Octanol, 3,7-dimethyl-1-01-00-00214BRN 1719638Citronellol, dihydro-DihydrocitronellolDimethyl octanolDimethyloctanol2,6-Dimethyl-8-octanol3,7-Dimethyl-1-octanolEINECS 203-374-5FEMA No. 2391Geraniol, perhydro-
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
27 records
FragranceDeodorizerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Europe | European Commission | Fl@vis |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =5.3 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| DPY9K1927C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| DPY9K1927C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| DPY9K1927C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| DPY9K1927C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 5184 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 9 of 9 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 3,7-dimethyloctan-1-ol | 203-374-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL3181881
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 3,7-Dimethyloctan-1-ol?
3,7-Dimethyloctan-1-ol appears on 6 regulatory/inventory lists including air; detected; emissions; Europe; Other direct contact consumer goods, detected; Europe; Other direct contact consumer goods, IFRA Transparency, and 3 more. Source: EPA CPDat.
Is 3,7-Dimethyloctan-1-ol used in cosmetics?
Yes, 3,7-Dimethyloctan-1-ol is also indexed as a cosmetic ingredient under the name Dihydrocitronellol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 3,7-Dimethyloctan-1-ol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 3,7-Dimethyloctan-1-ol used outside industrial chemicals?
3,7-Dimethyloctan-1-ol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.