Is DIETHYLENETRIAMINE safe in cosmetics?
DIETHYLENETRIAMINE has a safety rating of "GOOD" in our database. EU status: permitted. 2 toxicological study endpoint(s) are available in our database.
DIETHYLENETRIAMINE
Also known as: 1,2-Ethanediamine, N-(2-aminoethyl)-, 4-04-00-01238, Aminoethylethandiamine, Barsamide 115, Bis(beta-aminoethyl)amine (+7 more)
DIETHYLENETRIAMINE (CAS 111-40-0) is a cosmetic cosmetic ingredient functioning as Not Reported. Reported NOAEL =30 mg/kg bw/day in Rat (ECHA); EU Regulation 1223/2009 status: permitted; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 111-40-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
DIETHYLENETRIAMINE is classified GHS Danger (H302, H312, H314, H317, H318, H330, H335, H334) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Not Reported
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
N'-(2-aminoethyl)ethane-1,2-diamine
InChIKey
RPNUMPOLZDHAAY-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
2 study endpoints found for DIETHYLENETRIAMINE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =30 mg/kg bw/day | oral | Rat | developmental | ECHA |
| NOAEL | =100 mg/kg bw/day | oral | Rat | reproduction developmental | ECHA |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
SkullToxicCorr
Hazard Statements
Fatal if inhaled Harmful if swallowed or in contact with skin Causes severe skin burns and eye damage May cause an allergic skin reaction
Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. The effects may be delayed. Medical observation is indicated. See Notes.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Harmful / IrritantCorrosive
Hazard Class and Category
Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1B; Skin Sens. 1
Hazard Statements
- H312 Harmful in contact with skin
- H302 Harmful if swallowed
- H314 Causes severe skin burns and eye damage
- H317 May cause an allergic skin reaction
Inserted via ATP: CLP00
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
5.7%
DPRA Lys %
2.3%
KeratinoSens IC50
2000 µM
LLNA EC3
5%
NESIL
6207 µg/cm²
LLNA: Moderate (1B)
GHS: 1B
Human: positive
Source: LLNA: Gerberick et al. (2005); DPRA: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008]; KS: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008]; HPPT: [27] Kligman AM (1966): https://doi.org/10.1038/jid.1966.160
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 6206.9 | - | - |
| OECD_DA_Human | - | 0 | - | - | 1A (Strong sensitizer) |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (3)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
ICSC Safety Card
0620
Source: WHO/JECFA
Skin Eye Respiratory Irritation
Diethylenetriamine ... is a skin, eye, and respiratory irritant.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Adhesion/cohesion promoter
Chelating agent
Chemical reaction regulator
Corrosion inhibitor
Hardener
No specific technical function
Processing aids not otherwise specified
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for DIETHYLENETRIAMINE.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to DIETHYLENETRIAMINE by CAS number or substance name.
Studies
2
Lowest NOAEL
30 mg/kg bw/day
Highest NOAEL
100 mg/kg bw/day
ECHA
Known Synonyms
1,2-Ethanediamine, N-(2-aminoethyl)-
4-04-00-01238
Aminoethylethandiamine
Barsamide 115
Bis(beta-aminoethyl)amine
BRN 0605314
Diethylamine, 2,2'-diamino-
EINECS 203-865-4
Ethylamine, 2,2'-iminobis-
Imino-bis-ethylamine
UNII-03K6SX4V2J
dien
Chemical Function
Hardener
Regulatory Lists
drinking_water; Europe; manufacturing; plastic_additive
inert_ingredient; non_food_use; Pesticides
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Cons electronics mech appliances and machinery; Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL303429
Frequently Asked Questions
Is DIETHYLENETRIAMINE allowed in the EU?
DIETHYLENETRIAMINE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does DIETHYLENETRIAMINE do in cosmetics?
DIETHYLENETRIAMINE functions as: Not Reported. It is classified as a cosmetic ingredient in our database. CAS number: 111-40-0.
What is the NOAEL for DIETHYLENETRIAMINE?
The NOAEL (No Observed Adverse Effect Level) for DIETHYLENETRIAMINE is =30 mg/kg bw/day based on a developmental study via oral route in Rat. A total of 2 study endpoints are available. Source: ECHA.
Is DIETHYLENETRIAMINE classified as hazardous under GHS?
DIETHYLENETRIAMINE carries a GHS signal word of "DANGER". Hazard statements: Fatal if inhaled Harmful if swallowed or in contact with skin Causes severe skin burns and eye damage May cause an allergic skin reaction. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is DIETHYLENETRIAMINE used outside cosmetics?
DIETHYLENETRIAMINE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does DIETHYLENETRIAMINE have different safety status in cosmetics vs industrial chemicals?
DIETHYLENETRIAMINE is classified GHS Danger (H302, H312, H314, H317, H318, H330, H335, H334) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check DIETHYLENETRIAMINE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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