Is Diethyl Ethanolamine safe in cosmetics?
Diethyl Ethanolamine has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted. 5 toxicological study endpoint(s) are available in our database.
Diethyl Ethanolamine
Also known as: 2-Diethylamino ethanol, 2-Hydroxytriethylamine, Diethylmonoethanolamine, DEAE, Ethanol, 2-(diethylamino)- (+12 more)
INCI: DIETHYL ETHANOLAMINE
Diethyl Ethanolamine (CAS 100-37-8) is a cosmetic cosmetic ingredient functioning as pH adjuster, buffering agent. NOAEL 13.3333 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 100-37-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Diethyl Ethanolamine is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H290, H302, H312, H332, H311, H314, H318).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
pH adjuster, buffering agent
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
2-(diethylamino)ethanol
InChIKey
BFSVOASYOCHEOV-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted under 21 CFR; FDA guidance advises against nitrosamine contamination
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diethyl Ethanolamine.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Diethyl Ethanolamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 10 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 125 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | =20 mg/kg bw/day | oral | Dog | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =50 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =150 mg/kg bw/day | oral | Rabbit | developmental | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is corrosive to the eyes. The substance is severely irritating to the skin and respiratory tract. The substance may cause effects on the nervous system.
Routes of Exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Diethyl Ethanolamine across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
?FlammableHarmful / IrritantCorrosive
Hazard Class and Category
Flam. Liq. 3; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1B
Hazard Statements
- H226 Flammable liquid and vapour
- H332 Harmful if inhaled
- H312 Harmful in contact with skin
- H302 Harmful if swallowed
- H314 Causes severe skin burns and eye damage
Specific Concentration Limits / M-factors
STOT SE 3; H335: C ≥ 5.0%
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
0257
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Diethylaminoethanol vapor is a skin, eye, and respiratory irritant.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dispersing agent
Processing aids not otherwise specified
pH regulating agent
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Diethyl Ethanolamine.
Regulatory Flags
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Diethyl Ethanolamine by CAS number or substance name.
Studies
5
Lowest NOAEL
10 mg/kg bw/day
Highest NOAEL
150 mg/kg bw/day
COSMOS_DB
ToxValDB_ECHA_IUCLID
Known Synonyms
2-Diethylamino ethanol
2-Hydroxytriethylamine
Diethylmonoethanolamine
DEAE
Ethanol, 2-(diethylamino)-
beta-Diethylaminoethanol
N-Diethylaminoethanol
2-N-Diethylaminoethanol
beta-Diethylaminoethyl alcohol
N,N-Diethyl-N-(beta-hydroxyethyl)amine
N,N-Diethyl-2-hydroxyethylamine
EINECS 202-845-2
Diaethylaminoaethanol
UNII-S6DL4M053U
Diethyl(2-hydroxyethyl)amine
beta-(diethylamino)ethyl alcohol
beta-hydroxytriethylamine
Chemical Function
pH regulating agent
Dispersing agent
Processing aids not otherwise specified
Regulatory Lists
CEDI
inert_ingredient; non_food_use; Pesticides
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DIETHYLAMINOETHANOL
ChEMBL ID
CHEMBL1183
Frequently Asked Questions
Is Diethyl Ethanolamine allowed in the EU?
Diethyl Ethanolamine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Diethyl Ethanolamine do in cosmetics?
Diethyl Ethanolamine functions as: pH adjuster, buffering agent. It is classified as a cosmetic ingredient in our database. CAS number: 100-37-8.
What is the NOAEL for Diethyl Ethanolamine?
The NOAEL (No Observed Adverse Effect Level) for Diethyl Ethanolamine is 10 mg/kg bw/day based on a Carcinogenicity study via oral route in rat. A total of 5 study endpoints are available. Source: COSMOS_DB.
Is Diethyl Ethanolamine used outside cosmetics?
Diethyl Ethanolamine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Diethyl Ethanolamine have different safety status in cosmetics vs industrial chemicals?
Diethyl Ethanolamine is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H290, H302, H312, H332, H311, H314, H318).
Compliance Tools
Check Diethyl Ethanolamine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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