Also known as: 2-Diethylamino ethanol, 2-Hydroxytriethylamine, Diethylmonoethanolamine, DEAE, Ethanol, 2-(diethylamino)- (+12 more)
CAS 100-37-8
N,N-Diethylethanolamine (CAS 100-37-8) is a chemical substance with GHS signal word Danger; key hazard signal: H226; H332; H312; H302; H314. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
N,N-Diethylethanolamine is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H332, H312, H302, H314).
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 3; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1B | H226; H332; H312; H302; H314 | ?; GHS02; GHS07; GHS05 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is corrosive to the eyes. The substance is severely irritating to the skin and respiratory tract. The substance may cause effects on the nervous system. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 10 ppm (50 mg/m³) | 10 | 50 | Y |
| NIOSH | TWA | 10 ppm (50 mg/m³) | 10 | 50 | Y |
| ACGIH | TWA | 2 ppm [1991] | 2 | - | Y |
| CAL/OSHA | TWA | 2 ppm (9.6 mg/m³) | 2 | 9.6 | Y |
| NIOSH | IDLH | 100 ppm | 100 | - | - |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =10.7 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =18.3 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 94.7 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| S6DL4M053U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S6DL4M053U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S6DL4M053U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S6DL4M053U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 0.66 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| 4.6 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =1300 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =7700 | mg/m3 | LEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =321141 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =120 | mg/m3 | LOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =40 | mg/kg bw/day | LOAEL | oral | Dog | ToxValDB_ECHA_IUCLID |
| - | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =160 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =486 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| 10 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =20 | mg/kg bw/day | NOAEL | oral | Dog | ToxValDB_ECHA_IUCLID |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 125 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| =150 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| 250 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 300 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| <=400 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 440 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =100 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 66 | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
Showing 30 of 30 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-diethylaminoethanol | 202-845-2 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
N,N-Diethylethanolamine (CAS 100-37-8) is classified under EU CLP Annex VI as Flam. Liq. 3; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1B with signal word Danger. Hazard statements: H226; H332; H312; H302; H314. Source: EU CLP Annex VI (ECHA).
N,N-Diethylethanolamine has 30 NOAEL studies in the database. The lowest reported value is 10.7 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
N,N-Diethylethanolamine appears on 3 regulatory/inventory lists including CEDI, inert_ingredient; non_food_use; Pesticides, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Occupational exposure limits for N,N-Diethylethanolamine are set by OSHA, NIOSH, ACGIH. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, N,N-Diethylethanolamine is also indexed as a cosmetic ingredient under the name Diethyl Ethanolamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
N,N-Diethylethanolamine is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H332, H312, H302, H314).
N,N-Diethylethanolamine also appears in cosmetics, pharmaceutical databases.