Is Dicalcium Phosphate safe in cosmetics?
Dicalcium Phosphate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Dicalcium Phosphate
Also known as: Phosphoric acid, calcium salt (1:1), Calcium phosphate dibasic, Calcium phosphate (CaHPO4), A-Tab, Anhydrous Emcompress (+14 more)
INCI: DICALCIUM PHOSPHATE
Dicalcium Phosphate (CAS 7757-93-9) is a cosmetic cosmetic ingredient functioning as abrasive, bulking agent, opacifying agent, oral care ingredient. Reported NOAEL =214 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 7757-93-9 →
Auto-generated CPSR Part A draft with source citations
Function
abrasive, bulking agent, opacifying agent, oral care ingredient
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
calcium hydrogen phosphate
InChIKey
FUFJGUQYACFECW-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR Safety Assessment. OTC drug ingredient.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dicalcium Phosphate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Dicalcium Phosphate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =214 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
EPA ToxValDB — Toxicity Values
8 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | >7940 mg/kg | Rabbit | dermal | acute | ECHA IUCLID |
| LD50 | >7940 mg/kg | Rabbit | dermal | acute | ECHA IUCLID |
| LD50 | >7940 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | >10000 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | >10000 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | ~7940 mg/kg | Rat | oral | - | ECHA IUCLID |
| NOAEL | =214 mg/kg-day | Rat | oral | short-term | ECHA IUCLID |
| RfD | =8 mg/kg-day | Human | oral | - | RSL |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100,000 - 1,000,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
Skin and eye irritant.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Evaluation
CALCIUM HYDROGEN PHOSPHATE | 1982 | Group MTDI for phosphorus from all sources, expressed as P | TRS 683-JECFA 26/25 | FAS 17-JECFA 26/151
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Abrasive
Anti-caking agent
Biocide
Drier
Emulsifier
Filler
Flavouring and nutrient
Humectant
Leavening agent
Opacifer
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Dicalcium Phosphate.
Regulatory Flags
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Dicalcium Phosphate by CAS number or substance name.
Studies
1
Lowest NOAEL
214 mg/kg bw/day
Highest NOAEL
214 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Phosphoric acid, calcium salt (1:1)
Calcium phosphate dibasic
Calcium phosphate (CaHPO4)
A-Tab
Anhydrous Emcompress
Bekapress
Biofos
Calcium acid phosphate
Calcium dibasic phosphate
Calcium hydrogen orthophosphate
Calcium hydrogen phosphate (CaHPO4)
Calcium monohydrogen orthophosphate
Calcium monohydrogen phosphate
Calcium orthophosphate (CaHPO4)
Calcium phosphate (1:1)
Calcium secondary phosphate
D.C.P. 340
DCP
DCPA
Chemical Function
Abrasive
Opacifer
Filler
Flavouring and nutrient
Biocide
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
inert_ingredient; non_food_use; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; applied; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; agricultural; Pesticides
agricultural; detected; fruits_and_vegetables; Pesticides; residue
agricultural; detected; fruits_and_vegetables; Pesticides; residue
agricultural; detected; fruits_and_vegetables; Pesticides; residue
agricultural; detected; fruits_and_vegetables; Pesticides; residue
agricultural; detected; fruits_and_vegetables; Pesticides; residue
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CALCIUM PHOSPHATE, DIBASIC
ChEMBL ID
CHEMBL2107567
Max Phase
-1
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Dicalcium phosphate
E Number
E341ii
ADI
40 mg/kg bw
Food Category
flavor_enhancer
Frequently Asked Questions
Is Dicalcium Phosphate allowed in the EU?
Dicalcium Phosphate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dicalcium Phosphate do in cosmetics?
Dicalcium Phosphate functions as: abrasive, bulking agent, opacifying agent, oral care ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 7757-93-9.
What is the NOAEL for Dicalcium Phosphate?
The NOAEL (No Observed Adverse Effect Level) for Dicalcium Phosphate is =214 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Dicalcium Phosphate used outside cosmetics?
Dicalcium Phosphate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dicalcium Phosphate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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