Is Diallyldisulphide safe in cosmetics?
Diallyldisulphide has a safety rating of "POOR" in our database. EU status: prohibited. US status: restricted.
Poor
Cosmetic Ingredient
Diallyldisulphide
Also known as: Disulfide, di-2-propenyl, Allyl disulphide, BRN 1699241, EINECS 218-548-6, FEMA No. 2028 (+6 more)
INCI: DIALLYL DISULFIDE
Diallyldisulphide (CAS 2179-57-9) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. NOAEL 26.6667 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2179-57-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Diallyldisulphide is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H301, H315, H317, H319).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance ingredient
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
3-(prop-2-enyldisulfanyl)prop-1-ene
InChIKey
PFRGXCVKLLPLIP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
restricted
US Notes
Permitted — GRAS (FEMA) for food; not specifically restricted in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diallyldisulphide.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Diallyldisulphide across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 675 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
572
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ALLYL DISULFIDE | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/32 | FAS 44-JECFA 53/125
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Diallyldisulphide.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
Disulfide, di-2-propenyl
Allyl disulphide
BRN 1699241
EINECS 218-548-6
FEMA No. 2028
2-Propenyl disulfide
2-Propenyl disulphide
UNII-5HI47O6OA7
3,3'-disulfanediylbis(prop-1-ene)
3,3'-dithiobis(prop-1-ene)
3-(allyldisulfanyl)-1-propene
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
active_ingredient; Pesticides
Europe
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DIALLYLDISULFIDE
ChEMBL ID
CHEMBL366603
Frequently Asked Questions
Is Diallyldisulphide allowed in the EU?
Diallyldisulphide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Diallyldisulphide do in cosmetics?
Diallyldisulphide functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 2179-57-9.
Is Diallyldisulphide used outside cosmetics?
Diallyldisulphide also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Diallyldisulphide have different safety status in cosmetics vs industrial chemicals?
Diallyldisulphide is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H301, H315, H317, H319).
Compliance Tools
Check Diallyldisulphide compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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