NOAEL Studies Cosmetic Ingredient

Diallyl Sulphide NOAEL Studies

INCI: DIALLYL SULFIDE

CAS: 592-88-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 500 mg/kg bw/day rat oral 42 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 200 mg/kg bw/day rat oral 13 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 71 mg/kg bw/day mouse oral 4 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 114 mg/kg bw/day rat oral 4 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 20 mg/kg bw/day rat oral 42 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 50 mg/kg bw/day rat oral 29 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 100 mg/kg bw/day mouse oral 3 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =250 mg/kg bw/day Unspecified - 90 days subchronic EFSA CEF - 2011 - OutputID 2120 - Scientific Opinion on Flavouring Group Evaluation 74, Revision 2 (FGE.74Rev2): Consideration of Simple Aliphatic Sulphides and Thiols evaluated by the JECFA (53rd and 61st meeting) Structurally related to Aliphatic and Alicyclic Mono-, Di-, Tri-, and Polysulphides with or without Additional Oxygenated Functional Groups from Chemical Group 20 evaluated by EFSA in FGE.08Rev3 (2011). - doi:10.2903/j.efsa.2011.2458
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=8538; Record_ID=skin_sensitization_invivo_1920; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6060470; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1980: report to RIFM|Anonymous 1988; Not available; 10.1016/0278-6915(88)90150-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6060470
NTP_ICE_skin_sensitization Induction dose per skin area 337.5 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=8536; Record_ID=skin_sensitization_invivo_1920; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6060470; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=337.5; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1980: report to RIFM|Anonymous 1988; Not available; 10.1016/0278-6915(88)90150-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6060470
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=8542; Record_ID=skin_sensitization_invivo_1920; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6060470; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1980: report to RIFM|Anonymous 1988; Not available; 10.1016/0278-6915(88)90150-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6060470
ToxValDB_ECOTOX 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =500 mg/kg bw/day Rat oral short-term; 4 days short-term LONG_REF=Drug Metab. Dispos.35(6): 995-1000 Fisher,C.D., L.M. Augustine, J.M. Maher, D.M. Nelson, A.L. Slitt, C.D. Klaassen, L.D. Lehman-McKeeman, and N.J. Cherrin Induction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2 2007; TITLE=Induction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2; AUTHOR=Fisher,C.D., L.M. Augustine, J.M. Maher, D.M. Nelson, A.L. Slitt, C.D. Klaassen, L.D. Lehman-McKeeman, and N.J. Cherrin; DOI=10.1124/dmd.106.014340; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=109368; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Genetics: CYP2B1/2 mRNA|Genetics: Nqo1 mRNA; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15595423:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c6aa4a6decc500da121984697377da33
ToxValDB_ECOTOX NOEL =80 mg/kg bw/day Rat oral subchronic; 42 days subchronic LONG_REF=Food Chem. Toxicol.39(6): 563-569 Wu,C.C., L.Y. Sheen, H.W. Chen, S.J. Tsai, and C.K. Lii Effects of Organosulfur Compounds from Garlic Oil on the Antioxidation System in Rat Liver and Red Blood Cells 2001; TITLE=Effects of Organosulfur Compounds from Garlic Oil on the Antioxidation System in Rat Liver and Red Blood Cells; AUTHOR=Wu,C.C., L.Y. Sheen, H.W. Chen, S.J. Tsai, and C.K. Lii; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109481; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Biochemistry: Glutathione (reduced glutathione)|Enzyme(s): Glutathione reductase|Enzyme(s): Glutathione S-transferase|Enzyme(s): Superoxide dismutase (SOD) enzyme activity|Growth: Weight gain|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|enzyme activity|organ weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599859_15605422_15605423:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=29d9a3629367e424b92485feed23c37c
ToxValDB_ECOTOX NOEL =20 mg/kg bw/day Rat oral subchronic; 42 days subchronic LONG_REF=Food Chem. Toxicol.39(6): 563-569 Wu,C.C., L.Y. Sheen, H.W. Chen, S.J. Tsai, and C.K. Lii Effects of Organosulfur Compounds from Garlic Oil on the Antioxidation System in Rat Liver and Red Blood Cells 2001; TITLE=Effects of Organosulfur Compounds from Garlic Oil on the Antioxidation System in Rat Liver and Red Blood Cells; AUTHOR=Wu,C.C., L.Y. Sheen, H.W. Chen, S.J. Tsai, and C.K. Lii; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109481; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Enzyme(s): Glutathione peroxidase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599859_15605422_15605423:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8589326933dc91d092d4b9b36d2e287d
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =250 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=EFSA CEF (2014). Scientific Opinion on Flavouring Group Evaluation 74, Revision 3 (FGE.74Rev3): Consideration of Simple Aliphatic Sulphides and Thiols evaluated by the JECFA (53rd and 61st meeting) Structurally related to Aliphatic and Alicyclic Mono-, Di-, Tri-, and Polysulphides with or without Additional Oxygenated Functional Groups from Chemical Group 20 evaluated by EFSA in FGE.08Rev5 (2012). doi:10.2903/j.efsa.2014.3710.; TITLE=Scientific Opinion on Flavouring Group Evaluation 74, Revision 3 (FGE.74Rev3): Consideration of Simple Aliphatic Sulphides and Thiols evaluated by the JECFA (53rd and 61st meeting) Structurally related to Aliphatic and Alicyclic Mono-, Di-, Tri-, and Polysulphides with or without Additional Oxygenated Functional Groups from Chemical Group 20 evaluated by EFSA in FGE.08Rev5 (2012); AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2014.3710; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2014; ORIGINAL_YEAR=2014; STUDY_GROUP=EFSA:15622041:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3ef686b20375aa8b3ae8bebdd68ed559
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 60G7CF7CWZ UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H10S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"60G7CF7CWZ"}
openFDA substances FDA UNII substance identifier 60G7CF7CWZ UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H10S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"60G7CF7CWZ"}
openFDA substances FDA UNII substance identifier 60G7CF7CWZ UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H10S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"60G7CF7CWZ"}
openFDA substances FDA UNII substance identifier 60G7CF7CWZ UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H10S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"60G7CF7CWZ"}