Is Curcuma Longa Root Extract safe in cosmetics?
Curcuma Longa Root Extract has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Curcuma Longa Root Extract
Also known as: Curcumin I, (1E,6E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, C.I. 75300, Turmeric (dye), trans,trans-Curcumin (+15 more)
INCI: CURCUMA LONGA ROOT EXTRACT
Curcuma Longa Root Extract (CAS 458-37-7) is a cosmetic active ingredient functioning as Antioxidant, skin conditioning, anti-inflammatory. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 458-37-7 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, skin conditioning, anti-inflammatory
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA pre-market approval required for cosmetic use. Curcumin (CI 75300) is an FDA-approved color additive for food (21 CFR 73.600). Not approved as OTC drug active. No CIR final safety assessment for cosmetic use. MoCRA safety substantiation required. No GRAS listing relevant to topical use.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Curcuma Longa Root Extract.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for Curcuma Longa Root Extract based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
botanical
EU Allergen Listed
no
Patch Test Positive Rate
0.3%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
Source: IVDK; literature review
EPA ToxValDB — Toxicity Values
5 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| NOEL | =100 mg/kg-day | Rat | oral | short-term | ECOTOX |
| NOEL | =1000 mg/kg-day | Rat | oral | acute | ECOTOX |
| NOAEL | >=250 mg/kg-day | Rat | oral | chronic | EFSA |
| ADI | <=3 mg/kg | Human | oral | - | WHO JECFA ADI |
| LD50 | >2000 mg/kg | Mouse | oral | - | ChemIDplus |
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_colorant | - | All cosmetics (Class 1) |
| ASEAN | permitted_colorant | - | All products |
Additional Ingredient Properties
2 property records from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "botanical", "patch_test_frequency_pct": "0.3", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "IVDK; literature review"}
anti_aging
{"anti_aging_claim": "anti-inflammatory, brightening, antioxidant-protection", "mechanism_of_action": "Curcumin, turmerone", "target_skin_layer": "epidermis", "collagen_stimulation": "No", "elastin_protection": "Mild", "wrinkle_reduction_pct": "8-15", "clinical_study_duration_weeks": "8", "sample_size": "30", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "Phytotherapy Re…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Dye
Expert Verdict
Expert safety assessment and concern-level summary for Curcuma Longa Root Extract.
Regulatory Flags
eu-unrestricted
no-sccs-opinion
no-cir-assessment
ci-75300-color-additive-us
poor-bioavailability
nano-delivery-investigated
heavy-metal-contamination-risk
ayurvedic-supply-chain
clinical-trials-ongoing
antioxidant
anti-inflammatory
skin-brightening
Known Synonyms
Curcumin I
(1E,6E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
C.I. 75300
Turmeric (dye)
trans,trans-Curcumin
4-08-00-03697
BRN 2306965
EINECS 207-280-5
NCI-C61325
NSC 687842
Kurkumin
Zlut prirodni 3
1,5-Divanillyliden-2,4-pentandion
1,5-Di(vanillyliden)acetylaceton
UNII-IT942ZTH98
1,9-Bis(4-hydroxy-3-methoxyphenyl)-2,7-nonadiene-4,6-dione
C.I. Natural Yellow 3
CI Natural Yellow 3
Cucurmin
Diferaloylmethane
Chemical Function
Antioxidant
Dye
Regulatory Lists
Arts and crafts/Office supplies - body paint; detected; Europe
Arts and crafts/Office supplies - body paint; detected; Europe
Canada; pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
general_foods
Canada; pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CURCUMIN
ChEMBL ID
CHEMBL140
Max Phase
3
Adverse Event Associations
348
Frequently Asked Questions
Is Curcuma Longa Root Extract allowed in the EU?
Curcuma Longa Root Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Curcuma Longa Root Extract do in cosmetics?
Curcuma Longa Root Extract functions as: Antioxidant, skin conditioning, anti-inflammatory. It is classified as a Active Ingredient in our database. CAS number: 458-37-7.
Is Curcuma Longa Root Extract used outside cosmetics?
Curcuma Longa Root Extract also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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Good
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(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
CI 75300 (Curcumin)
Good
Chemical family
Colorant. Natural polyphenol pigment ...
Curcumin
Good
Chemical family
Colorant, Antioxidant
CURCUBITURILS
Good
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