Is CI 75300 (Curcumin) safe in cosmetics?
CI 75300 (Curcumin) has a safety rating of "GOOD" in our database. EU status: permitted. US status: prohibited.
Good
Cosmetic Ingredient
CI 75300 (Curcumin)
Also known as: Curcumin I, (1E,6E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, C.I. 75300, Turmeric (dye), trans,trans-Curcumin (+15 more)
INCI: CI 75300
CI 75300 (Curcumin) (CAS 458-37-7) is a cosmetic cosmetic ingredient functioning as Colorant. Natural polyphenol pigment extracted from the rhizome of Curcuma. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in food safety data.
View industrial chemical safety profile for CAS 458-37-7 →
Auto-generated CPSR Part A draft with source citations
Function
Colorant. Natural polyphenol pigment extracted from the rhizome of Curcuma longa (turmeric); also known as Curcumin, Natural Yellow 3, and food colorant E100. Imparts bright yellow-orange coloration to cosmetic products. Water-soluble and fat-soluble forms available.
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
prohibited
US Notes
FDA delisted Curcumin as a color additive effective July 2, 1966 (31 FR 9105) after it was only provisionally listed for food use with no ongoing commercial interest. Curcumin is not listed in 21 CFR Parts 73 or 74 as an approved color additive for cosmetics or drugs. While curcumin may be used as a cosmetic ingredient for its functional properties (antioxidant, skin-conditioning), its use as a declared color additive in US cosmetics is not formally supported under FDA color additive regulations.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 75300 (Curcumin).
Calculate MoS for your specific formulation with the MoS Calculator.
EPA ToxValDB — Toxicity Values
5 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| NOEL | =100 mg/kg-day | Rat | oral | short-term | ECOTOX |
| NOEL | =1000 mg/kg-day | Rat | oral | acute | ECOTOX |
| NOAEL | >=250 mg/kg-day | Rat | oral | chronic | EFSA |
| ADI | <=3 mg/kg | Human | oral | - | WHO JECFA ADI |
| LD50 | >2000 mg/kg | Mouse | oral | - | ChemIDplus |
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_colorant | - | All cosmetics (Class 1) |
| ASEAN | permitted_colorant | - | All products |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
colorant
{"Common_Name": "Curcumin", "Chemical_Name": "Curcumin", "CAS_Number": "458-37-7", "Colorant_Type": "Natural Colorant", "Approved_Uses": "All cosmetics", "Max_Concentration_%": "No limit", "EU_Status": "Approved", "US_FDA_Status": "Approved", "Notes": "Yellow from turmeric"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Dye
Expert Verdict
Expert safety assessment and concern-level summary for CI 75300 (Curcumin).
Regulatory Flags
natural-colorant
polyphenol
eu-annex-iv
turmeric-derived
e100
fda-delisted-1966
not-fda-cosmetic-color-listing
antioxidant
anti-inflammatory
food-grade-origin
Known Synonyms
Curcumin I
(1E,6E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
C.I. 75300
Turmeric (dye)
trans,trans-Curcumin
4-08-00-03697
BRN 2306965
EINECS 207-280-5
NCI-C61325
NSC 687842
Kurkumin
Zlut prirodni 3
1,5-Divanillyliden-2,4-pentandion
1,5-Di(vanillyliden)acetylaceton
UNII-IT942ZTH98
1,9-Bis(4-hydroxy-3-methoxyphenyl)-2,7-nonadiene-4,6-dione
C.I. Natural Yellow 3
CI Natural Yellow 3
Cucurmin
Diferaloylmethane
Chemical Function
Antioxidant
Dye
Regulatory Lists
Arts and crafts/Office supplies - body paint; detected; Europe
Arts and crafts/Office supplies - body paint; detected; Europe
Canada; pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
general_foods
Canada; pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives + fda_gras_enriched
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Curcumin
E Number
E100
ADI
3 mg/kg bw
FDA GRAS
FDA has no questions; some uses may require a color additive listing
GRN
686
Food Category
colorant
Intended for use as a nutrient supplement in yogurt, nutrition bars, smoothies, and medical foods) at levels intended to provide up to 60 milligrams of curcumin per serving
View full food safety profile →Frequently Asked Questions
Is CI 75300 (Curcumin) allowed in the EU?
CI 75300 (Curcumin) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 75300 (Curcumin) do in cosmetics?
CI 75300 (Curcumin) functions as: Colorant. Natural polyphenol pigment extracted from the rhizome of Curcuma longa (turmeric); also known as Curcumin, Natural Yellow 3, and food colorant E100. Imparts bright yellow-orange coloration to cosmetic products. Water-soluble and fat-soluble forms available.. It is classified as a cosmetic ingredient in our database. CAS number: 458-37-7.
Is CI 75300 (Curcumin) used outside cosmetics?
CI 75300 (Curcumin) also appears in food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check CI 75300 (Curcumin) compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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