What is the NOAEL for Curcumin?
Curcumin has 16 NOAEL studies in the database. The lowest reported value is 3 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.
NOAEL Data
Cosmetic Ingredient
Curcumin
Also known as: Curcumin I, (1E,6E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, C.I. 75300, Turmeric (dye), trans,trans-Curcumin (+15 more)
CAS 458-37-7
Curcumin (CAS 458-37-7) is a chemical substance. Key regulatory status: 10 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
View cosmetic safety profile for Curcuma Longa Root Extract →
SOURCE
noael studies public
NOAEL studies
16
SOURCE
chemical inventory jurisdictions
Regulatory lists
10
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Curcumin
CAS Number
458-37-7
DTXSID
DTXSID8031077
Molecular Formula
C21H20O6
InChI Key
VFLDPWHFBUODDF-FCXRPNKRSA-N
Monoisotopic Mass
368.125988
Synonyms
Curcumin I(1E,6E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dioneC.I. 75300Turmeric (dye)trans,trans-Curcumin4-08-00-03697BRN 2306965EINECS 207-280-5NCI-C61325NSC 687842KurkuminZlut prirodni 3
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
AntioxidantDye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
10 records
| List | Keyword | Source |
|---|---|---|
| Arts and crafts/Office supplies - body paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| general_foods | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 16 of 16 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=3 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| =3 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =3 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| 297 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| IT942ZTH98 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| IT942ZTH98 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| IT942ZTH98 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| IT942ZTH98 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4.14e-8 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| =2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >=250 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >=250 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >=250 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =100 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECOTOX |
| =1000 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECOTOX |
Showing 16 of 16 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CURCUMIN
ChEMBL Phase
3
Adverse Events
348
Bioactivity
13
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
2 records
E100 — ADI: 3 mg/kg bw | FDA GRAS: FDA has no questions; some uses may require a color additive listing
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Curcumin?
Curcumin appears on 4 regulatory/inventory lists including Arts and crafts/Office supplies - body paint; detected; Europe, Canada; pharmaceutical, general_foods, and 1 more. Source: EPA CPDat.
Is Curcumin used in cosmetics?
Yes, Curcumin is also indexed as a cosmetic ingredient under the name Curcuma Longa Root Extract. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Curcumin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Curcumin used outside industrial chemicals?
Curcumin also appears in cosmetics, pharmaceutical, food safety, cannabis databases.