Is Cupric Chloride safe in cosmetics?
Cupric Chloride has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 4 toxicological study endpoint(s) are available in our database.
Cupric Chloride
Also known as: CuCl2, EINECS 231-210-2, Cupric chloride in plastic container, UNII-P484053J2Y, Coclor (+5 more)
INCI: CUPRIC CHLORIDE
Cupric Chloride (CAS 7447-39-4) is a cosmetic cosmetic ingredient functioning as Cosmetic colorant (CI 77402 when used as colorant); oral-care agent. Reported NOAEL =16 mg/kg bw/day in Rat (EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 7447-39-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Cupric Chloride is prohibited in EU cosmetics but has active industrial GHS classifications (H290, H302, H312, H315, H318, H319, H400, H410).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Cosmetic colorant (CI 77402 when used as colorant); oral-care agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
dichlorocopper
InChIKey
ORTQZVOHEJQUHG-UHFFFAOYSA-L
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Not independently affirmed by FDA as a color additive for cosmetics; copper compounds generally recognized but lack specific CIR final safety assessment for this salt. FDA does not restrict general cosmetic use but does not list it as an approved color additive.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cupric Chloride.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Cupric Chloride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =16 mg/kg bw/day | oral: unspecified | Rat | subchronic | EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx |
| NOAEL | =16 mg/kg bw/day | oral: unspecified | Rat | subchronic | EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx |
| NOAEL | =78 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =185 mg/kg bw/day | oral | Mouse | chronic | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Skin Eye Respiratory Irritation
Contact with solutions irritates eyes; contact with solid causes ... eye surface injury. ... | IRRITATING TO SKIN, MUCOUS MEMBRANES.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Cupric Chloride.
Regulatory Flags
colorant
endocrine_disruptor
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Cupric Chloride by CAS number or substance name.
Studies
4
Lowest NOAEL
16 mg/kg bw/day
Highest NOAEL
185 mg/kg bw/day
ToxValDB_ECHA_IUCLID
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx
Known Synonyms
CuCl2
EINECS 231-210-2
Cupric chloride in plastic container
UNII-P484053J2Y
Coclor
Copper chloride
Copper chloride (CuCl2)
Copper(2+)chloride
Copper(II) chloride (1:2)
Cupric chloride anhydrous
Chemical Function
Softener and conditioner
Regulatory Lists
active_ingredient; Europe; Pesticides
Canada; pharmaceutical
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
cupric chloride
ChEMBL ID
CHEMBL1200553
Adverse Event Associations
2
Frequently Asked Questions
Is Cupric Chloride allowed in the EU?
Cupric Chloride EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Cupric Chloride do in cosmetics?
Cupric Chloride functions as: Cosmetic colorant (CI 77402 when used as colorant); oral-care agent. It is classified as a cosmetic ingredient in our database. CAS number: 7447-39-4.
What is the NOAEL for Cupric Chloride?
The NOAEL (No Observed Adverse Effect Level) for Cupric Chloride is =16 mg/kg bw/day based on a subchronic study via oral: unspecified route in Rat. A total of 4 study endpoints are available. Source: EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx.
Is Cupric Chloride used outside cosmetics?
Cupric Chloride also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Cupric Chloride have different safety status in cosmetics vs industrial chemicals?
Cupric Chloride is prohibited in EU cosmetics but has active industrial GHS classifications (H290, H302, H312, H315, H318, H319, H400, H410).
Compliance Tools
Check Cupric Chloride compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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