NOAEL Data REACH Registered Cosmetic Ingredient

Copper(II) chloride

Also known as: CuCl2, EINECS 231-210-2, Cupric chloride in plastic container, UNII-P484053J2Y, Coclor (+5 more)

CAS 7447-39-4

Copper(II) chloride (CAS 7447-39-4) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Cupric Chloride →

Cross-Vertical Regulatory Divergence

Copper(II) chloride is prohibited in EU cosmetics but has active industrial GHS classifications (H290, H302, H312, H315, H318, H319, H400, H410).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 16 fields

Name

Copper(II) chloride

CAS Number

7447-39-4

DTXSID

DTXSID7040449

Molecular Formula

2ClH.Cu

InChI Key

ORTQZVOHEJQUHG-UHFFFAOYSA-L

Monoisotopic Mass

134.882953

Synonyms

CuCl2EINECS 231-210-2Cupric chloride in plastic containerUNII-P484053J2YCoclorCopper chlorideCopper chloride (CuCl2)Copper(2+)chlorideCopper(II) chloride (1:2)Cupric chloride anhydrous

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 1 records

Softener and conditioner

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records

List	Keyword	Source
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
Canada; pharmaceutical	DrugBank	DrugBank
Canada; pharmaceutical	DrugBank	DrugBank

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 30 of 30 studies

Value	Unit	Endpoint	Route	Species	Source
=0.15	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx
35.71	min	Breakthrough Time	Dermal	-	NTP_ICE_skin_irritation
=1	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
0.4	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
0.4	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
0.4	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
0.4	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
P484053J2Y	UNII	FDA UNII substance identifier	-	-	openFDA substances
P484053J2Y	UNII	FDA UNII substance identifier	-	-	openFDA substances
P484053J2Y	UNII	FDA UNII substance identifier	-	-	openFDA substances
P484053J2Y	UNII	FDA UNII substance identifier	-	-	openFDA substances
=156	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=370	mg/kg bw/day	LOAEL	oral	Mouse	ToxValDB_ECHA_IUCLID
>1500	ppm	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=0.192	mg/kg bw/day	LOEL	oral	Rat	ToxValDB_ECOTOX
=0.2	mg/m3	LOEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=64	mg/L	LOEL	oral	Rat	ToxValDB_ECOTOX
=110	mg/kg bw/day	LOEL	oral	Mouse	ToxValDB_ECOTOX
=1000	mg/L	LOEL	oral	Rat	ToxValDB_ECOTOX
>=2	mg/m3	NOAEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=16	mg/kg bw/day	NOAEL	oral: unspecified	Rat	EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx
=16	mg/kg bw/day	NOAEL	oral: unspecified	Rat	EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx
=78	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=185	mg/kg bw/day	NOAEL	oral	Mouse	ToxValDB_ECHA_IUCLID
=1000	ppm	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=50	mg/L	NOEL	oral	Rat	ToxValDB_ECOTOX
=76.8	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECOTOX
=100	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECOTOX
=200	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECOTOX
=300	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECOTOX

Showing 30 of 30 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Copper dichloride	231-210-2	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL cupric chloride

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Copper(II) chloride?

Copper(II) chloride has 30 NOAEL studies in the database. The lowest reported value is 0.15 mg/kg bw/day in Consumers. Source: EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx.

What regulatory lists include Copper(II) chloride?

Copper(II) chloride appears on 2 regulatory/inventory lists including active_ingredient; Europe; Pesticides, Canada; pharmaceutical. Source: EPA CPDat.

Is Copper(II) chloride used in cosmetics?

Yes, Copper(II) chloride is also indexed as a cosmetic ingredient under the name Cupric Chloride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Copper(II) chloride come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Copper(II) chloride have different safety status in cosmetics vs industrial chemicals?

Copper(II) chloride is prohibited in EU cosmetics but has active industrial GHS classifications (H290, H302, H312, H315, H318, H319, H400, H410).

Is Copper(II) chloride used outside industrial chemicals?

Copper(II) chloride also appears in cosmetics, pharmaceutical, cannabis databases.