Is Cinnamaldehyde Dimethyl Acetal safe in cosmetics?
Cinnamaldehyde Dimethyl Acetal has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Cinnamaldehyde Dimethyl Acetal
Also known as: Cinnamaldehyde dimethyl acetyl, Cinnamic aldehyde dimethyl acetal, 3-Phenyl-2-propenal dimethyl acetal, 3,3-Dimethoxy-1-phenylprop-1-ene, Benzene, (3,3-dimethoxy-1-propenyl)- (+3 more)
INCI: CINNAMALDEHYDE DIMETHYL ACETAL
Cinnamaldehyde Dimethyl Acetal (CAS 4364-06-1) is a cosmetic cosmetic ingredient functioning as Fragrance. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 4364-06-1 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
[(E)-3,3-dimethoxyprop-1-enyl]benzene
InChIKey
MBAOABFNWSOOLU-CMDGGOBGSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Safety Rating
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cinnamaldehyde Dimethyl Acetal.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
6480 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [138] Kligman AM (1972): Report to RIFM, 25 August, unpublished.
HRIPT Human Patch Test Studies
3 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 92 | 0 | 827 | 827 | non-sensitizer |
| HMT | - | 0 | 6480 | - | - |
| HMT | - | 0 | 6480 | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for Cinnamaldehyde Dimethyl Acetal.
Regulatory Flags
fragrance-component
ifra_fragrance
Known Synonyms
Cinnamaldehyde dimethyl acetyl
Cinnamic aldehyde dimethyl acetal
3-Phenyl-2-propenal dimethyl acetal
3,3-Dimethoxy-1-phenylprop-1-ene
Benzene, (3,3-dimethoxy-1-propenyl)-
Benzene, (3,3-dimethoxy-1-propen-1-yl)-
(3,3-Dimethoxy-1-propenyl)benzene
EINECS 224-454-6
Chemical Function
Fragrance
Regulatory Lists
IFRA Transparency
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Cinnamaldehyde Dimethyl Acetal allowed in the EU?
Cinnamaldehyde Dimethyl Acetal EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cinnamaldehyde Dimethyl Acetal do in cosmetics?
Cinnamaldehyde Dimethyl Acetal functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 4364-06-1.
Compliance Tools
Check Cinnamaldehyde Dimethyl Acetal compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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