What is the NOAEL for Iron(III) oxide?
Iron(III) oxide has 9 NOAEL studies in the database. The lowest reported value is 1K09F3G675 UNII. Source: openFDA substances.
NOAEL Data
IARC Group 3
REACH Registered
Cosmetic Ingredient
Iron(III) oxide
Also known as: C.I. Pigment Red 102, C.I. Pigment Red 101 and 102, Anchred standard, Anhydrous iron oxide, Anhydrous oxide of iron (+14 more)
CAS 1309-37-1
Iron(III) oxide (CAS 1309-37-1) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 23 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC, OSHA.
View cosmetic safety profile for Iron Oxides (CI 77491, CI 77492, CI 77499) →
SOURCE
noael studies public
NOAEL studies
9
SOURCE
chemical inventory jurisdictions
Regulatory lists
23
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Iron(III) oxide
CAS Number
1309-37-1
DTXSID
DTXSID0029632
Molecular Formula
2Fe.3O
InChI Key
LIKBJVNGSGBSGK-UHFFFAOYSA-N
Monoisotopic Mass
159.854617
Synonyms
C.I. Pigment Red 102C.I. Pigment Red 101 and 102Anchred standardAnhydrous iron oxideAnhydrous oxide of ironArmenian boleBauxite residueBlack oxide of ironBlended red oxides of ironBurnt siennaBurnt umberBurntisland Red
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1987 | 1, Sup 7 |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | May cause mechanical irritation. |
| Long-term Effects | Repeated or prolonged inhalation of dust particles may cause effects on the lungs. This may result in siderosis, a benign condition. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
3 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 15 mg/m³ (total dust), 5 mg/m³ (respirable fraction) | - | 15 | N |
| ACGIH | TWA | 5 mg/m³ (respirable particulate matter) [2005] | - | 5 | N |
| CAL/OSHA | TWA | 10 mg/m³ (total dust), 5 mg/m³ (respirable fraction) | - | 10 | N |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
DyePigmentBinderFlux agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
23 records
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - dental care - toothpaste | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Europe; Personal care | European Commission | CosIng |
| Arts and crafts/Office supplies - body paint - tattoo ink; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; Europe | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 1K09F3G675 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1K09F3G675 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1K09F3G675 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1K09F3G675 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| >1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 9 of 9 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Diiron trioxide | 215-168-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Colorant / Inorganic Pigment
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ferric oxide
ChEMBL Phase
Not listed
Adverse Events
14
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: 0.5 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Iron(III) oxide?
Iron(III) oxide appears on 14 regulatory/inventory lists including Indirect additives food contact (10/2018), children; Europe; Personal care, children; Europe; Personal care - specialized bath products - bath salts, and 11 more. Source: EPA CPDat.
Is Iron(III) oxide a carcinogen according to IARC?
Iron(III) oxide is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
What are the occupational exposure limits for Iron(III) oxide?
Occupational exposure limits for Iron(III) oxide are set by OSHA, ACGIH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Iron(III) oxide used in cosmetics?
Yes, Iron(III) oxide is also indexed as a cosmetic ingredient under the name Iron Oxides (CI 77491, CI 77492, CI 77499). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Iron(III) oxide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Iron(III) oxide used outside industrial chemicals?
Iron(III) oxide also appears in cosmetics, pharmaceutical, food safety, cannabis databases.