Is CI 41000 (Auramine O / Basic Yellow 2) safe in cosmetics?
CI 41000 (Auramine O / Basic Yellow 2) has a safety rating of "POOR" in our database. EU status: prohibited. US status: prohibited.
Poor
Cosmetic Ingredient
CI 41000 (Auramine O / Basic Yellow 2)
Also known as: Benzophenoneidum, C.I. Basic Yellow No. 2, Auramine-O, Aizen Auramine Conc. SFA, Aniline, 4,4'-imidocarbonylbis(N,N-dimethyl-, monohydrochloride (+15 more)
INCI: CI 41000
CI 41000 (Auramine O / Basic Yellow 2) (CAS 2465-27-2) is a cosmetic cosmetic ingredient functioning as Colorant. Synthetic diarylmethane yellow dye (Auramine O, also known as Basic. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2465-27-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
CI 41000 (Auramine O / Basic Yellow 2) is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H311, H319, H351, H373, H400, H410, H411).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Colorant. Synthetic diarylmethane yellow dye (Auramine O, also known as Basic Yellow 2, C.I. Basic Yellow 2). Produces bright yellow coloration. Primarily an industrial, histological, and laboratory staining dye rather than a cosmetic colorant. Used in textile dyeing, paper, leather, and fluorescence microscopy.
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
4-[4-(dimethylamino)benzenecarboximidoyl]-N,N-dimethylaniline;hydrochloride
InChIKey
KSCQDDRPFHTIRL-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
prohibited
US Notes
CI 41000 (Auramine O / Basic Yellow 2) is not listed on the FDA Color Additives Permitted for Use in Cosmetics (21 CFR Parts 73, 74, or 82). It has no established FDA color additive listing for cosmetic use. Use in US cosmetics is not authorized. Auramine O is recognized by IARC and NTP as a probable human carcinogen (Group 2A) based on occupational exposure studies.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 41000 (Auramine O / Basic Yellow 2).
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Evidence for Carcinogenicity
The Human Health Assessment Group in EPA's Office of Health and Environmental Assessment has evaluated auramine for carcinogenicity. According to their analysis, the weight-of-evidence for auramine is group B2, which is based on inadequate evidence in humans and sufficient evidence in animals. As a group B2 chemical, auramine is considered probably carcinogenic to humans. /Auramine/ | Auramine, te
Source: Hazardous Substances Data Bank (HSDB)
Expert Verdict
Expert safety assessment and concern-level summary for CI 41000 (Auramine O / Basic Yellow 2).
Regulatory Flags
not-in-eu-annex-iv
eu-prohibited-by-omission
not-fda-listed
no-cosmetic-authorization
iarc-group-2a-probable-carcinogen
ntp-carcinogen
industrial-dye-only
cationic-dye
dna-binding
occupational-hazard
Known Synonyms
Benzophenoneidum
C.I. Basic Yellow No. 2
Auramine-O
Aizen Auramine Conc. SFA
Aniline, 4,4'-imidocarbonylbis(N,N-dimethyl-, monohydrochloride
Auramine O Extra Conc. A Export
Auramine Extra
Auramine Extra Conc. A
Basic Yellow 2, fugitive
4,4'-Bis(dimethylamino)-benzhydrylidenimine hydrochloride
CI Basic Yellow 2
CI Basic Yellow 2, monohydrochloride
EINECS 219-567-2
NSC 4045
NSC 47707
NSC 93737
(Tetramethyldiamino)diphenylketoimine hydrochloride
Zlut zasadita 2
Auramine, monohydrochloride
UNII-DL992L7W39
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1612246
Frequently Asked Questions
Is CI 41000 (Auramine O / Basic Yellow 2) allowed in the EU?
CI 41000 (Auramine O / Basic Yellow 2) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 41000 (Auramine O / Basic Yellow 2) do in cosmetics?
CI 41000 (Auramine O / Basic Yellow 2) functions as: Colorant. Synthetic diarylmethane yellow dye (Auramine O, also known as Basic Yellow 2, C.I. Basic Yellow 2). Produces bright yellow coloration. Primarily an industrial, histological, and laboratory staining dye rather than a cosmetic colorant. Used in textile dyeing, paper, leather, and fluorescence microscopy.. It is classified as a cosmetic ingredient in our database. CAS number: 2465-27-2.
Is CI 41000 (Auramine O / Basic Yellow 2) used outside cosmetics?
CI 41000 (Auramine O / Basic Yellow 2) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does CI 41000 (Auramine O / Basic Yellow 2) have different safety status in cosmetics vs industrial chemicals?
CI 41000 (Auramine O / Basic Yellow 2) is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H311, H319, H351, H373, H400, H410, H411).
Compliance Tools
Check CI 41000 (Auramine O / Basic Yellow 2) compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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