Also known as: 2-Naphthalenesulfonic acid, 8-hydroxy-5,7-dinitro-, sodium salt (1:2), 2-Naphthalenesulfonic acid, 5,7-dinitro-8-hydroxy-, disodium salt, C.I. Acid Yellow 1, disodium 5,7-dinitro-8-oxidonaphthalene-2-sulphonate, 1307 Yellow (+15 more)
INCI: CI 10316
CI 10316 (Ext. D&C Yellow No. 7) (CAS 846-70-8) is a cosmetic cosmetic ingredient functioning as Colorant. Synthetic nitro dye (Disodium 5,7-dinitro-8-oxidonaphthalene-2-sulphon. EU Regulation 1223/2009 status: restricted, max Permitted in all cosmetics except those applied in the vicinity of the eyes and lip products; no maximum concentration specified. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 846-70-8 →
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 10316 (Ext. D&C Yellow No. 7).
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for CI 10316 (Ext. D&C Yellow No. 7). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | = mg/kg bw/day | - | guinea pig | developmental toxicity | SCCNFP_vision_codex |
| NOAEL | = mg/kg bw/day | - | guinea pig | developmental toxicity | SCCNFP_vision_codex |
| NOAEL | = mg/kg bw/day | - | guinea pig | developmental toxicity | SCCNFP_vision_codex |
| NOAEL | = mg/kg bw/day | - | guinea pig | developmental toxicity | SCCNFP_vision_codex |
| NOAEL | =30 mg/kg bw/day | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =30 mg/kg bw/day | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =30 mg/kg bw/day | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =30 mg/kg bw/day | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =50 mg/kg bw/day | - | pig | developmental toxicity | SCCNFP_vision_codex |
| NOAEL | =50 mg/kg bw/day | - | pig | developmental toxicity | SCCNFP_vision_codex |
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_sccs_opinion | 0.096% | - | - | 2008-12-16 |
| measured_sccs_opinion | 0.078% | - | - | 2008-12-16 |
1 property record from structured ingredient metadata.
Expert safety assessment and concern-level summary for CI 10316 (Ext. D&C Yellow No. 7).
Public NOAEL study rows linked to CI 10316 (Ext. D&C Yellow No. 7) by CAS number or substance name.
Units vary across source rows: mg/kg bw/day, mg/kg bw
| Absorption % | Method | Vehicle |
|---|---|---|
| 0.096% | SCCS opinion extraction | - |
| 0.078% | SCCS opinion extraction | - |
CI 10316 (Ext. D&C Yellow No. 7) has a safety rating of "MODERATE" in our database. EU status: restricted. US status: restricted. 10 toxicological study endpoint(s) are available in our database.
CI 10316 (Ext. D&C Yellow No. 7) EU regulatory status: restricted. Maximum allowed concentration: Permitted in all cosmetics except those applied in the vicinity of the eyes and lip products; no maximum concentration specified. This is based on EU Regulation 1223/2009 and its amendments.
CI 10316 (Ext. D&C Yellow No. 7) functions as: Colorant. Synthetic nitro dye (Disodium 5,7-dinitro-8-oxidonaphthalene-2-sulphonate), also known as Naphthol Yellow S and Acid Yellow 1. Imparts yellow coloration to cosmetic products. Water-soluble anionic dye. Historically used as a food colorant but delisted from food use in the US in 1959. Now restricted to external-use cosmetics and drugs only.. It is classified as a cosmetic ingredient in our database. CAS number: 846-70-8.
The NOAEL (No Observed Adverse Effect Level) for CI 10316 (Ext. D&C Yellow No. 7) is =0 mg/kg bw/day based on a developmental toxicity study via oral route in guinea pig. A total of 10 study endpoints are available. Source: SCCNFP_vision_codex.
CI 10316 (Ext. D&C Yellow No. 7) also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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