Is CI 12120 (Pigment Red 3 / Toluidine Red) safe in cosmetics?
CI 12120 (Pigment Red 3 / Toluidine Red) has a safety rating of "POOR" in our database. EU status: restricted. US status: prohibited.
Poor
Cosmetic Ingredient
CI 12120 (Pigment Red 3 / Toluidine Red)
Also known as: C.P. Toluidine Toner A-2989, C.P. Toluidine Toner A-2990, C.P. Toluidine Toner Dark RS-3340, C.P. Toluidine Toner Deep X-1865, C.P. Toluidine Toner Light RS-3140 (+15 more)
INCI: CI 12120
CI 12120 (Pigment Red 3 / Toluidine Red) (CAS 2425-85-6) is a cosmetic cosmetic ingredient functioning as Colorant. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2425-85-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
CI 12120 (Pigment Red 3 / Toluidine Red) is classified GHS Danger (H318, H410, H413) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Chemistry & Identifiers
IUPAC Name
1-[(4-methyl-2-nitrophenyl)diazenyl]naphthalen-2-ol
InChIKey
ZLFVRXUOSPRRKQ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
prohibited
US Notes
Formerly listed as D&C Red No. 35; delisted by FDA in September 1966 (81.30(d)). No currently approved use in US cosmetics, drugs, or food. Health Canada's Cosmetic Ingredient Hotlist lists it as prohibited.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 12120 (Pigment Red 3 / Toluidine Red).
Calculate MoS for your specific formulation with the MoS Calculator.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
57
Evaluation Year
1992
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex IV — Permitted Colorants
Product type: Red
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (IV - Colorants)
Product type: Rinse-off products.
BRIN Brazil/India Cosmetics
India: Permitted Colorant
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_colorant | 3 | All cosmetics (Class 1) |
| CA | banned | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (4)
Carcinogen Classification
CI Pigment Red 3 | Group 3: Not classifiable as to its carcinogenicity to humans | Volume 57: (1993) Occupational Exposures of Hairdressers and Barbers and Personal Use of Hair Colourants; Some Hair Dyes, Cosmetic Colourants, Industrial Dyestuffs and Aromatic Amines
Source: International Agency for Research on Cancer (IARC)
Carcinogen Classification
C.I. Pigment Red 3 | TR-407: Toxicology and Carcinogenesis Studies of C.I. Pigment Red 3 (CASRN 2425-85-6) in F344/N Rats and B6C3F1 Mice (Feed Studies) (1992 ) | 07/09/91 | Some Evidence | Some Evidence | Some Evidence | No Evidence | Under the conditions of these 2-year feed studies, there was some evidence of carcinogenic activity of C.I. Pigment Red 3 in male F344/N rats as exhibited
Source: NTP Technical Reports
Evidence for Carcinogenicity
Evaluation: There is inadequate evidence in humans for the carcinogenicity of CI Pigment Red 3. There is limited evidence in experimental animals for the carcinogenicity of CI Pigment Red 3. Overall evaluation: CI Pigment Red 3 cannot be classified as to its carcinogenicity to humans (Group 3).
Source: Hazardous Substances Data Bank (HSDB)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Pigment
Regulatory List Membership (2)
EU Regulated in Personal Care
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for CI 12120 (Pigment Red 3 / Toluidine Red).
Regulatory Flags
fda-delisted-1966
iarc-group-3
carcinogenic-in-animals
canada-prohibited
rinse-off-only-eu
azo-dye
aromatic-amine-precursor
eu-annex-iv-restricted
eu_cosing_listed
Known Synonyms
C.P. Toluidine Toner A-2989
C.P. Toluidine Toner A-2990
C.P. Toluidine Toner Dark RS-3340
C.P. Toluidine Toner Deep X-1865
C.P. Toluidine Toner Light RS-3140
C.P. Toluidine Toner RT-6101
C.P. Toluidine Toner RT-6104
Basoflex Red 361
CI Pigment Red 3
CP Toluidine toner A-2989
Dainichi Permanent Red 4 R
EINECS 219-372-2
Eljon Fast Scarlet PV Extra
Graphtol Red A-4RL
Irgalite Fast Red P4R
Irgalite Red PV2
Isol Fast Red RN2B
Isol Fast Red RN2G
Isol Toluidine Red RN2B
Isol Toluidine Red RN2G
Chemical Function
Dye
Pigment
Regulatory Lists
Europe; Personal care
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL2138372
Frequently Asked Questions
Is CI 12120 (Pigment Red 3 / Toluidine Red) allowed in the EU?
CI 12120 (Pigment Red 3 / Toluidine Red) EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 12120 (Pigment Red 3 / Toluidine Red) do in cosmetics?
CI 12120 (Pigment Red 3 / Toluidine Red) functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 2425-85-6.
Is CI 12120 (Pigment Red 3 / Toluidine Red) used outside cosmetics?
CI 12120 (Pigment Red 3 / Toluidine Red) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does CI 12120 (Pigment Red 3 / Toluidine Red) have different safety status in cosmetics vs industrial chemicals?
CI 12120 (Pigment Red 3 / Toluidine Red) is classified GHS Danger (H318, H410, H413) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check CI 12120 (Pigment Red 3 / Toluidine Red) compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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