NOAEL Data IARC Group 3 REACH Registered Cosmetic Ingredient

C.I. Pigment Red 3

Also known as: C.P. Toluidine Toner A-2989, C.P. Toluidine Toner A-2990, C.P. Toluidine Toner Dark RS-3340, C.P. Toluidine Toner Deep X-1865, C.P. Toluidine Toner Light RS-3140 (+15 more)

CAS 2425-85-6

C.I. Pigment Red 3 (CAS 2425-85-6) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH.

View cosmetic safety profile for CI 12120 (Pigment Red 3 / Toluidine Red) →

Cross-Vertical Regulatory Divergence

C.I. Pigment Red 3 is classified GHS Danger (H318, H410, H413) in the chemicals database but is restricted in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

C.I. Pigment Red 3

CAS Number

2425-85-6

DTXSID

DTXSID8021226

Molecular Formula

C17H13N3O3

InChI Key

ZLFVRXUOSPRRKQ-UHFFFAOYSA-N

Monoisotopic Mass

307.095691

Synonyms

C.P. Toluidine Toner A-2989C.P. Toluidine Toner A-2990C.P. Toluidine Toner Dark RS-3340C.P. Toluidine Toner Deep X-1865C.P. Toluidine Toner Light RS-3140C.P. Toluidine Toner RT-6101C.P. Toluidine Toner RT-6104Basoflex Red 361CI Pigment Red 3CP Toluidine toner A-2989Dainichi Permanent Red 4 REINECS 219-372-2

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records

Group	Meaning	Evaluated	Volume
Group 3	Not classifiable	1992	57

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records

DyePigment

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records

List	Keyword	Source
Europe; Personal care	European Commission	CosIng
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe	Danish Environmental Protection Agency	Danish EPA
inert_ingredient; non_food_use; Pesticides	EPA	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 13 of 13 studies

Value	Unit	Endpoint	Route	Species	Source
7K26S08256	UNII	FDA UNII substance identifier	-	-	openFDA substances
7K26S08256	UNII	FDA UNII substance identifier	-	-	openFDA substances
7K26S08256	UNII	FDA UNII substance identifier	-	-	openFDA substances
7K26S08256	UNII	FDA UNII substance identifier	-	-	openFDA substances
3	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
3	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
3	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
3	unitless	IARC group	-	-	NTP_ICE_cancer
12500	ppm	POLY-3 lowest dose	Dosed feed	Rat	NTP_ICE_cancer
25000	ppm	POLY-3 lowest dose	Dosed feed	Rat	NTP_ICE_cancer
50000	ppm	POLY-3 lowest dose	Dosed feed	Mouse	NTP_ICE_cancer
2.5	%	Top dose	Dosed feed	Rat	NTP_ICE_cancer
5	%	Top dose	Dosed feed	Mouse	NTP_ICE_cancer

Showing 13 of 13 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	1-(4-methyl-2-nitrophenylazo)-2-naphthol	219-372-2	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL2138372

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for C.I. Pigment Red 3?

C.I. Pigment Red 3 has 13 NOAEL studies in the database. The lowest reported value is 7K26S08256 UNII. Source: openFDA substances.

What regulatory lists include C.I. Pigment Red 3?

C.I. Pigment Red 3 appears on 3 regulatory/inventory lists including Europe; Personal care, Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe, inert_ingredient; non_food_use; Pesticides. Source: EPA CPDat.

Is C.I. Pigment Red 3 a carcinogen according to IARC?

C.I. Pigment Red 3 is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1992). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is C.I. Pigment Red 3 used in cosmetics?

Yes, C.I. Pigment Red 3 is also indexed as a cosmetic ingredient under the name CI 12120 (Pigment Red 3 / Toluidine Red). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for C.I. Pigment Red 3 come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does C.I. Pigment Red 3 have different safety status in cosmetics vs industrial chemicals?

C.I. Pigment Red 3 is classified GHS Danger (H318, H410, H413) in the chemicals database but is restricted in EU cosmetics.

Is C.I. Pigment Red 3 used outside industrial chemicals?

C.I. Pigment Red 3 also appears in cosmetics, pharmaceutical databases.