Is Carmine (CI 75470) safe in cosmetics?
Carmine (CI 75470) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Carmine (CI 75470)
Also known as: B Rose liquid, Carmine (Coccus cacti L.), Cochineal (Coccus cacti L.), Cochineal extract lake, EINECS 215-724-4 (+8 more)
Carmine (CI 75470) (CAS 1390-65-4) is a cosmetic cosmetic ingredient functioning as Deodorizer; Dye; Flavouring and nutrient. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 1390-65-4 →
Auto-generated CPSR Part A draft with source citations
Function
Deodorizer; Dye; Flavouring and nutrient
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Carmine (CI 75470).
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for Carmine (CI 75470) based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
dye
EU Allergen Listed
no
Patch Test Positive Rate
0.3%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
Source: IVDK; NACDG
Dermal Penetration Profile
Skin absorption and penetration characteristics of Carmine (CI 75470), relevant to systemic exposure and MoS calculations.
Absorption %
0.1-0.5%
Penetration Level
surface
Penetration Depth
surface only
Molecular Weight
Variable Da
Log P
n/a
Systemic Absorption
minimal
Topical Bioavailability
0.05-0.2%
Safety Margin Factor
minimal
Vehicle Dependent
Yes — absorption varies by formulation
Source: CIR
EPA ToxValDB — Toxicity Values
2 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | >2000 mg/kg | Rat | oral | - | ECHA IUCLID |
| ADI | <=5 mg/kg | Human | oral | - | WHO JECFA ADI |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE; GROUP
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (4)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_colorant | - | All cosmetics (Class 1) |
| GCC | halal_restricted | - | All cosmetics |
| BR | permitted_colorant | - | Column 1: All products |
| ASEAN | permitted_colorant | - | All products |
Additional Ingredient Properties
8 property records from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "dye", "patch_test_frequency_pct": "0.3", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "IVDK; NACDG"}
dermal_absorption
{"molecular_weight_da": "Variable", "skin_penetration_level": "surface", "penetration_depth": "surface only", "absorption_pct": "0.1-0.5", "systemic_absorption": "minimal", "penetration_enhancer": "no", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "neutral", "bioavailability_topical_pct": "0.05-0.2", "safety_margin_factor": "minimal", "source": "CIR"}
pediatric_safety
{"safe_for_newborn_0_6m": "caution", "safe_for_infant_6_12m": "caution", "safe_for_toddler_1_3y": "yes", "safe_for_child_3_12y": "yes", "safe_for_teen_12_18y": "yes", "pediatric_max_concentration_pct": "unlimited", "adult_max_concentration_pct": "unlimited", "pediatric_dermal_absorption_factor": "normal", "immature_skin_barrier_risk": "low", "oral_ingestion_risk": "low", "eye_irritation_risk": "lo…
ph_stability
{"optimal_ph_min": "4.0", "optimal_ph_max": "7.0", "stable_ph_min": "3.5", "stable_ph_max": "8.0", "degrades_above_ph": "8.5", "degrades_below_ph": "3.0", "ph_dependent_function": "Red pigment; pH affects shade", "formulation_note": "Natural red dye from insects", "source": "Formulation literature"}
pregnancy_detail
{"pregnancy_safe": "yes", "breastfeeding_safe": "yes", "risk_category": "not-rated", "reason": "Safe; insect-derived colorant", "source": "dermatology literature"}
sensory
{"silky": "powdery", "smooth, glides easily": "smooth, pigment", "dry-touch, non-greasy": "tinted, matte", "instant": "fast", "low": "low", "w/o": "o/w", "very-high": "moderate", "no": "no", "yes": "no", "light-diffusing": "matte", "1.40": "1.50", "transparent": "opaque", "colorless": "red", "excellent": "fair", "light": "light", "synthetic": "botanical"}
supply_chain
{"primary_producing_countries": "Peru, Spain, Chile", "secondary_producing_countries": "Canary Islands, Mexico, Bolivia", "raw_material_origin": "animal", "agricultural_crop_or_wild_harvested": "insect_harvesting", "cultivation_climate_required": "cochineal_cultivation", "harvest_season": "continuous", "annual_global_production_tonnes": "520", "market_share_top_producer_pct": "68", "supply_chain_l…
uv_stability
{"uv_stable": "partially", "uv_degradation_rate": "moderate", "photosensitizer": "no", "phototoxic": "no", "photoallergic": "no", "requires_uv_protection_packaging": "yes", "color_change_uv": "yes", "odor_change_uv": "yes", "efficacy_loss_uv_pct": "30", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Dye
Flavouring and nutrient
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Carmine (CI 75470).
Regulatory Flags
fda_food_additive
Known Synonyms
B Rose liquid
Carmine (Coccus cacti L.)
Cochineal (Coccus cacti L.)
Cochineal extract lake
EINECS 215-724-4
FEMA No. 2242
FEMA No. 2330
Carmine aluminum lake
Carmine red
CC 1000WS
CCRIS 1204
215-724-4
EC No.: 215-724-4
Chemical Function
Deodorizer
Dye
Flavouring and nutrient
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Carmine (CI 75470) allowed in the EU?
Carmine (CI 75470) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Carmine (CI 75470) do in cosmetics?
Carmine (CI 75470) functions as: Deodorizer; Dye; Flavouring and nutrient. It is classified as a cosmetic ingredient in our database. CAS number: 1390-65-4.
Is Carmine (CI 75470) used outside cosmetics?
Carmine (CI 75470) also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Carmine (CI 75470) compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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CI 75470 (Carmine)
Good
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Carmine
Moderate
Chemical family
colorant
Cochineal (CI 75470 / Carmine)
Good
Chemical family
Colorant, masking agent
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