Is CAPSAICIN safe in cosmetics?
CAPSAICIN has a safety rating of "GOOD" in our database. EU status: permitted. US status: restricted.
Good
Cosmetic Ingredient
CAPSAICIN
Also known as: Qutenza, (6E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide, Adlea, ALGRX 4975, Ausanil (+14 more)
CAPSAICIN (CAS 404-86-4) is a cosmetic cosmetic ingredient functioning as Fragrance, Skin Conditioning. NOAEL 0.0166667 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 404-86-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
CAPSAICIN is classified GHS Danger (H301, H315, H317, H319, H334, H335, H302, H318) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance, Skin Conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
InChIKey
YKPUWZUDDOIDPM-SOFGYWHQSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
CIR: SQ - IJT 26(Suppl. 1):3-106, 2007
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CAPSAICIN.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for CAPSAICIN across SCCS product categories, with measured dermal absorption where available.
Additional Ingredient Properties
1 property record from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "anti-inflammatory, antioxidant-protection", "mechanism_of_action": "Specialized bioactive mechanism", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "8-15", "clinical_study_duration_weeks": "12", "sample_size": "28", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "Specia…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
Not listed by IARC.
Source: Toxin and Toxin Target Database (T3DB)
Skin Eye Respiratory Irritation
Contact with products containing capsaicin produces local irritation and lacrimation. | Powerful irritant; initial administration causes burning pain. | Based on the application methods and formulation types, the potential for eye, dermal, and inhalation exposure to mixers, loaders, and applicators does exist. In addition the potential for post-application exposure may be significant from the foli
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Pharmaceutical
Softener and conditioner
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for CAPSAICIN.
Regulatory Flags
cosing-sourced
eu-permitted
skin-conditioning
fragrance
needs-enrichment
fda_food_additive
Known Synonyms
Qutenza
(6E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
Adlea
ALGRX 4975
Ausanil
Axsain
Capsicin
Chilli Orange
Ovocap
trans-Capsaicin
N-(4-oxy-3-methoxybenzyl)-8-methyl-6-nonenamide
(6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
EC No.: 206-969-8
BRN 2816484
Caswell No. 158
EINECS 206-969-8
EPA Pesticide Chemical Code 070701
FEMA No. 3404
N-(4-Hydroxy-3-methoxybenzyl)-8-methylnon-trans-6-enamide
Chemical Function
Deodorizer
Softener and conditioner
Fragrance
Pharmaceutical
Flavouring and nutrient
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
active_ingredient; agricultural; applied; Pesticides
active_ingredient; agricultural; applied; Pesticides
pharmaceutical
pharmaceutical
pharmaceutical
pharmaceutical
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; Pesticides
Europe; pharmaceutical
air; Cleaning products and household care - air freshener; detected; emissions; Europe
Canada; pharmaceutical
Cleaning products and household care - air freshener; Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CAPSAICIN
ChEMBL ID
CHEMBL294199
Max Phase
4
Adverse Event Associations
1576
Frequently Asked Questions
Is CAPSAICIN allowed in the EU?
CAPSAICIN EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CAPSAICIN do in cosmetics?
CAPSAICIN functions as: Fragrance, Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 404-86-4.
Is CAPSAICIN used outside cosmetics?
CAPSAICIN also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does CAPSAICIN have different safety status in cosmetics vs industrial chemicals?
CAPSAICIN is classified GHS Danger (H301, H315, H317, H319, H334, H335, H302, H318) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check CAPSAICIN compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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