What is the NOAEL for Capsaicin?
Capsaicin has 84 NOAEL studies in the database. The lowest reported value is 2.5e-8 mmol via injection in Mouse. Source: ToxValDB_ECOTOX.
NOAEL Data
Cosmetic Ingredient
Capsaicin
Also known as: Qutenza, (6E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide, Adlea, ALGRX 4975, Ausanil (+14 more)
CAS 404-86-4
Capsaicin (CAS 404-86-4) is a chemical substance. Key regulatory status: 18 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
Cross-Vertical Regulatory Divergence
Capsaicin is classified GHS Danger (H301, H315, H317, H319, H334, H335, H302, H318) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
84
SOURCE
chemical inventory jurisdictions
Regulatory lists
18
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Capsaicin
CAS Number
404-86-4
DTXSID
DTXSID9020241
Molecular Formula
C18H27NO3
InChI Key
YKPUWZUDDOIDPM-SOFGYWHQSA-N
Monoisotopic Mass
305.199094
Synonyms
Qutenza(6E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamideAdleaALGRX 4975AusanilAxsainCapsicinChilli OrangeOvocaptrans-CapsaicinN-(4-oxy-3-methoxybenzyl)-8-methyl-6-nonenamide(6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
8 records
DeodorizerSoftener and conditionerFragrancePharmaceuticalFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
18 records
| List | Keyword | Source |
|---|---|---|
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| active_ingredient; agricultural; applied; Pesticides | Arizona Department of Environmental Quality | State of Arizona |
| active_ingredient; agricultural; applied; Pesticides | Arizona Department of Environmental Quality | State of Arizona |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| Europe; pharmaceutical | European Medicines Agency | PROTECT ADR database |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 84 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1.7 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =1.7 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =24 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =24 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| S07O44R1ZM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S07O44R1ZM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S07O44R1ZM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S07O44R1ZM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =148 | mg/kg bw | LD50 | oral | Rat (Female) | NTP_ICE_acute_oral |
| =161 | mg/kg bw | LD50 | oral | Rat (Male) | NTP_ICE_acute_oral |
| =5e-7 | mmol | LOEL | injection | Mouse | ToxValDB_ECOTOX |
| =0.00048 | mg | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =0.001 | mg/org | LOEL | injection | Mouse | ToxValDB_ECOTOX |
| =0.003 | ml/cm2 | LOEL | dermal | European Rabbit | ToxValDB_ECOTOX |
| =0.0065 | ml/cm2 | LOEL | dermal | European Rabbit | ToxValDB_ECOTOX |
| =0.01 | mg/org | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =0.015 | mg/org | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =0.015 | mg | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =0.025 | mg | LOEL | injection | Dog | ToxValDB_ECOTOX |
| =0.04 | mg | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =0.05 | mg/kg bw/day | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =0.07 | mg | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =0.1 | mg/kg bw/day | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =0.1 | % | LOEL | dermal | Rat | ToxValDB_ECOTOX |
| =0.2 | mg/kg bw/day | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =0.2 | mg | LOEL | injection | European Rabbit | ToxValDB_ECOTOX |
| =0.3 | mg/kg bw/day | LOEL | injection | Dog | ToxValDB_ECOTOX |
| =0.4 | mg | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =0.5 | mg/day | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =0.5 | % | LOEL | dermal | Dog | ToxValDB_ECOTOX |
| =1 | % | LOEL | dermal | Rat | ToxValDB_ECOTOX |
| =1.8 | mg/kg bw/day | LOEL | injection | Mouse | ToxValDB_ECOTOX |
| =1.94 | mg/kg bw/day | LOEL | injection | Mouse | ToxValDB_ECOTOX |
| =3 | mg/kg bw/day | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =3 | % | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =5 | mg/kg bw/day | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =7.5 | mg/kg bw/day | LOEL | injection | Mouse | ToxValDB_ECOTOX |
| =10 | mg/kg bw/day | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =16 | mg/org | LOEL | dermal | Rat | ToxValDB_ECOTOX |
| =25 | mg/kg bw/day | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =30 | mg/L | LOEL | dermal | Dog | ToxValDB_ECOTOX |
| =30 | mg/kg bw/day | LOEL | injection | Dog | ToxValDB_ECOTOX |
| =32 | mg/org | LOEL | dermal | Rat | ToxValDB_ECOTOX |
| =40 | mM | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =40 | mg/kg bw/day | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =50 | mg/kg bw/day | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =90 | mg/kg bw/day | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =125 | mg/kg bw/day | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =130 | mg/kg bw/day | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =150 | mg/kg bw/day | LOEL | injection | Rat | ToxValDB_ECOTOX |
Showing 50 of 84 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CAPSAICIN
ChEMBL Phase
4
Adverse Events
1576
Bioactivity
21
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Capsaicin?
Capsaicin appears on 10 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), active_ingredient; agricultural; applied; Pesticides, pharmaceutical, and 7 more. Source: EPA CPDat.
Is Capsaicin used in cosmetics?
Yes, Capsaicin is also indexed as a cosmetic ingredient under the name CAPSAICIN. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Capsaicin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Capsaicin have different safety status in cosmetics vs industrial chemicals?
Capsaicin is classified GHS Danger (H301, H315, H317, H319, H334, H335, H302, H318) in the chemicals database but is allowed in EU cosmetics.
Is Capsaicin used outside industrial chemicals?
Capsaicin also appears in cosmetics, pharmaceutical, food safety, cannabis databases.