What is the NOAEL for Acephylline?
Acephylline has 5 NOAEL studies in the database. The lowest reported value is M494UE2YEP UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Acephylline
Also known as: 5-26-14-00088, BRN 0279221, 7-(Carboxymethyl)theophylline, EINECS 211-490-2, NSC 52996 (+9 more)
CAS 652-37-9
Acephylline (CAS 652-37-9) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
20 fields
Name
Acephylline
CAS Number
652-37-9
DTXSID
DTXSID6057796
Molecular Formula
C9H10N4O4
InChI Key
HCYFGRCYSCXKNQ-UHFFFAOYSA-N
Monoisotopic Mass
238.070205
Synonyms
5-26-14-00088BRN 02792217-(Carboxymethyl)theophyllineEINECS 211-490-2NSC 529961,2,3,6-Tetrahydro-1,3-dimethyl-2,6-dioxopurine-7-acetic acidTheophyllineacetic acidTheophylline-7-acetic acid7-Theophyllinylacetic acid2-(p-Chlorphenoxy)-2-methylpropyl 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxopurine-7-acetate7-Theophyllinessigsaeure7-Theophyllinylessigsaeure
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Softener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| M494UE2YEP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| M494UE2YEP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| M494UE2YEP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| M494UE2YEP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =900 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Theophyllin-7-ylacetic acid | 211-490-2 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Skin Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ACEFYLLINE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
4
Frequently Asked Questions
What regulatory lists include Acephylline?
Acephylline appears on 1 regulatory/inventory list including Canada; pharmaceutical. Source: EPA CPDat.
Is Acephylline used in cosmetics?
Yes, Acephylline is also indexed as a cosmetic ingredient under the name Caffeine Carboxylic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Acephylline come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Acephylline used outside industrial chemicals?
Acephylline also appears in cosmetics, pharmaceutical databases.