Is CALCIUM ASCORBATE safe in cosmetics?
CALCIUM ASCORBATE has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
CALCIUM ASCORBATE
Also known as: Calcium ascorbate anhydrous, Hemicalcium ascorbate, Ascorbic acid calcium salt, Calci-C, Calcium L-ascorbate (+2 more)
CALCIUM ASCORBATE (CAS 5743-27-1) is a cosmetic cosmetic ingredient functioning as Antioxidant, Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 5743-27-1 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, Skin Conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
calcium bis((2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2H-furan-4-olate)
InChIKey
BLORRZQTHNGFTI-ZZMNMWMASA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR: S - IJT 24(Suppl. 2):51-111, 2005
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Additional Ingredient Properties
6 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "antioxidant-protection, brightening", "mechanism_of_action": "Cofactor for enzymatic reactions, antioxidant activity", "target_skin_layer": "epidermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "8-15", "clinical_study_duration_weeks": "12", "sample_size": "30", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal…
depigmentation
{"cas_number": "5743-27-1", "ingredient_class": "melanin_oxidation_agent", "primary_mechanism_of_action": "Calcium salt of vitamin C; buffered form", "secondary_mechanisms": "Variable", "molecular_target": "other", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reduction_pct_clinical": "15-30", "onset_of_v…
ph_stability
{"optimal_ph_min": "7.0", "optimal_ph_max": "7.3", "stable_ph_min": "6.5", "stable_ph_max": "7.5", "degrades_above_ph": "8.0", "degrades_below_ph": "6.0", "ph_dependent_function": "Stable aqueous calcium salt", "formulation_note": "Requires neutral pH 7-7.3", "source": "US Patent 2400171"}
skin_brightening
{"cas_number": "5743-27-1", "mechanism_of_action": "Water-soluble buffered vitamin C; mineral delivery", "melanogenesis_pathway_target": "Tyrosinase", "tyrosinase_inhibition_ic50_um": "~700-1000", "tyrosinase_inhibition_vs_kojic_acid": "~10-14x weaker", "melanosome_transfer_inhibitor": "No", "melanin_oxidation_reducer": "Partial", "endothelin_pathway_blocker": "No", "alpha_msh_antagonist": "No", "…
skin_suitability
{"oily_skin": "acceptable", "dry_skin": "acceptable", "sensitive_skin": "acceptable", "combination_skin": "acceptable", "normal_skin": "acceptable", "acne_prone": "acceptable", "rosacea": "acceptable", "eczema": "acceptable", "hyperpigmentation": "recommended", "aging_mature": "acceptable", "dehydrated": "acceptable", "skin_benefit_primary": "antioxidant", "skin_benefit_secondary": "brightening", …
vitamin
{"cas_number": "5743-27-1", "ingredient_class": "vitamin_C", "chemical_form": "salt", "derivative_type": "active_form", "molecular_weight_Da": "390.31", "water_solubility": "soluble", "oil_solubility": "insoluble", "log_P": "-3.00", "stability_to_light": "moderate", "stability_to_heat": "moderate", "stability_to_oxidation": "moderate", "stability_to_pH_acid": "good", "stability_to_pH_alkaline": "e…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (1)
JECFA Evaluation
CALCIUM ASCORBATE | 1981 | NOT SPECIFIED | Group ADI for ascorbic acid and its sodium, potassium and calcium salts | TRS 669-JECFA 25/32 | FAS 16-JECFA 25/52
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Softener and conditioner
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for CALCIUM ASCORBATE.
Regulatory Flags
cosing-sourced
eu-permitted
skin-conditioning
antioxidant
needs-enrichment
fda_food_additive
jecfa_safe
Known Synonyms
Calcium ascorbate anhydrous
Hemicalcium ascorbate
Ascorbic acid calcium salt
Calci-C
Calcium L-ascorbate
EINECS 227-261-5
UNII-J96U0ZD4Y6
Chemical Function
Antioxidant
Softener and conditioner
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Europe; supplements
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CALCIUM ASCORBATE
ChEMBL ID
CHEMBL2146095
Max Phase
-1
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Calcium ascorbate
E Number
E302
ADI
NOT SPECIFIED mg/kg bw
Food Category
preservative
Frequently Asked Questions
Is CALCIUM ASCORBATE allowed in the EU?
CALCIUM ASCORBATE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CALCIUM ASCORBATE do in cosmetics?
CALCIUM ASCORBATE functions as: Antioxidant, Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 5743-27-1.
Is CALCIUM ASCORBATE used outside cosmetics?
CALCIUM ASCORBATE also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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