What is the GHS hazard classification for Butyl butyrate?
Butyl butyrate (CAS 109-21-7) is classified under EU CLP Annex VI as Flam. Liq. 3 with signal word Warning. Hazard statements: H226. Source: EU CLP Annex VI (ECHA).
Warning
GHS02
NOAEL Data
REACH Registered
Cosmetic Ingredient
Butyl butyrate
Also known as: Butanoic acid, butyl ester, n-Butyl butyrate, Butyric acid, butyl ester, 4-02-00-00789, BRN 1747101 (+11 more)
CAS 109-21-7
Butyl butyrate (CAS 109-21-7) is a chemical substance with GHS signal word Warning; key hazard signal: H226. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
6
SOURCE
eu clp annex vi
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
22 fields
Name
Butyl butyrate
CAS Number
109-21-7
DTXSID
DTXSID7041702
Molecular Formula
C8H16O2
InChI Key
XUPYJHCZDLZNFP-UHFFFAOYSA-N
Monoisotopic Mass
144.11503
Synonyms
Butanoic acid, butyl estern-Butyl butyrateButyric acid, butyl ester4-02-00-00789BRN 1747101EINECS 203-656-8FEMA No. 2186UNII-1BHV00T1M4Butyl N-butyrateButyl ester of butanoic acidFEMA 2186N-Butyl N-butanoate
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
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EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 3 | H226 | GHS02 | Warning |
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
6 records
FragranceNo specific technical functionFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 1BHV00T1M4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1BHV00T1M4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1BHV00T1M4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1BHV00T1M4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2700 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Butyl butyrate | 203-656-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
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EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Butyl butyrate?
Butyl butyrate has 7 NOAEL studies in the database. The lowest reported value is 1BHV00T1M4 UNII. Source: openFDA substances.
What regulatory lists include Butyl butyrate?
Butyl butyrate appears on 6 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Australia; Food and drug - smoking-related products, IFRA Transparency, and 3 more. Source: EPA CPDat.
Is Butyl butyrate used in cosmetics?
Yes, Butyl butyrate is also indexed as a cosmetic ingredient under the name Butyl Butyrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Butyl butyrate come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Butyl butyrate used outside industrial chemicals?
Butyl butyrate also appears in cosmetics, food safety, cannabis databases.