Is Beta-Ionone safe in cosmetics?
Beta-Ionone has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Beta-Ionone
Also known as: (3E)-4-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-3-buten-2-one, (E)-4-(2,6,6-Trimethylcyclohex-1-enyl)but-3-en-2-one, 2-07-00-00140, BRN 1909544, EINECS 201-224-3 (+14 more)
INCI: BETA-IONONE
Beta-Ionone (CAS 79-77-6) is a cosmetic cosmetic ingredient functioning as Fragrance, Flavoring Substance. Reported NOAEL =750 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 79-77-6 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance, Flavoring Substance
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(E)-4-(2,6,6-trimethylcyclohexen-1-yl)but-3-en-2-one
InChIKey
PSQYTAPXSHCGMF-BQYQJAHWSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Not prohibited or restricted; allowed for cosmetic use; also GRAS as a flavoring substance
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Beta-Ionone.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Beta-Ionone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =750 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
2 property records from structured ingredient metadata.
fragrance
{"cas_number": "14901-07-6", "ingredient_class": "aroma_chemical", "chemical_class": "ionone", "odor_family": "floral", "odor_description": "Violet, woody, raspberry, floral", "odor_strength": "strong", "odor_tenacity_hours": "48.0", "top_note": "no", "heart_note": "yes", "base_note": "yes", "blending_factor_1_10": "8.0", "threshold_of_detection_ppb": "0.007", "molecular_weight_Da": "192.3", "boil…
fragrance_ifra
{"cas_number": "14901-07-6", "ifra_amendment_number": "49", "ifra_restriction_type": "Restricted", "ifra_max_use_level_category_1_pct": "0.11", "ifra_max_use_level_category_4_pct": "1.8", "ifra_max_use_level_category_7_pct": "0.26", "ifra_max_use_level_category_11_pct": "0.052", "eu_allergen_declaration_required": "No", "eu_26_allergens_list": "No", "sccs_opinion_available": "Yes", "sensitization_…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
389
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
beta-CYCLOCITRYLIDENEACETONE | 1998 | 0-0.1 mg/kg bw (1984) | No safety concern at current levels of intake when used as a flavouring agent. The 1984 group ADI of 0-0.1 mg/kg bw for alpha-ionone and beta-ionone, singly or in combination, was maintained at the fifty-first meeting (1998). | TRS 891-JECFA 51/96 | FAS 42-JECFA 51/335
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
beta-IONONE | 1998 | 0-0.1 mg/kg bw (1984) | No safety concern at current levels of intake when used as a flavouring agent. The 1984 group ADI of 0-0.1 mg/kg bw for alpha-ionone and beta-ionone, singly or in combination, was maintained at the fifty-first meeting (1998). | TRS 891-JECFA 51/96 | FAS 42-JECFA 51/335
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Beta-Ionone.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Beta-Ionone by CAS number or substance name.
Studies
3
Lowest NOAEL
10 mg/kg bw/day
Highest NOAEL
750 mg/kg bw/day
ToxValDB_ECHA_IUCLID
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
Known Synonyms
(3E)-4-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-3-buten-2-one
(E)-4-(2,6,6-Trimethylcyclohex-1-enyl)but-3-en-2-one
2-07-00-00140
BRN 1909544
EINECS 201-224-3
trans-4-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-3-buten-2-one
UNII-A7NRR1HLH6
(3E)-4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-one
(E)-beta -ionone
4-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-(E)-3-Buten-2-one
FEMA 2595
Ionone, beta
Trans-beta -ionone
[E]-4-[2,6,6-trimethyl-1-cyclohexen-1-yl]-3-buten-2-one
b-Ionone
beta -E-ionone
beta-E-Ionone
beta-Ionon
trans-beta-Ionone
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
BETA-IONONE
ChEMBL ID
CHEMBL559945
Frequently Asked Questions
Is Beta-Ionone allowed in the EU?
Beta-Ionone EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Beta-Ionone do in cosmetics?
Beta-Ionone functions as: Fragrance, Flavoring Substance. It is classified as a cosmetic ingredient in our database. CAS number: 79-77-6.
What is the NOAEL for Beta-Ionone?
The NOAEL (No Observed Adverse Effect Level) for Beta-Ionone is =750 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Beta-Ionone used outside cosmetics?
Beta-Ionone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Beta-Ionone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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