NOAEL Studies Cosmetic Ingredient

Beta-Ionone NOAEL Studies

INCI: BETA-IONONE

CAS: 79-77-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =750 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa8be4b0a7c65d1b6527; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18612/7/9/2?documentUUID=05c87ee8-bfb3-4cfa-9318-841d16293dc1; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=P0: mortality|P0: organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival|organ weight; STUDY_GROUP=ECHA IUCLID:15861459:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3815198524f1c5a5ddf81b8fc6769624
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOEL =10 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=EFSA CEF (2012). Scientific Opinion on Flavouring Group Evaluation 73, Revision 1 (FGE.73Rev1): Consideration of alicyclic primary alcohols, aldehydes, acids and related esters evaluated by JECFA (59th meeting) structurally related to primary saturated or unsaturated alicyclic alcohol, aldehyde, and esters evaluated by EFSA in FGE.12Rev2 (2011)EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF). doi:10.2903/j.efsa.2012.2638.; TITLE=Scientific Opinion on Flavouring Group Evaluation 73, Revision 1 (FGE.73Rev1): Consideration of alicyclic primary alcohols, aldehydes, acids and related esters evaluated by JECFA (59th meeting) structurally related to primary saturated or unsaturated alicyclic alcohol, aldehyde, and esters evaluated by EFSA in FGE.12Rev2 (2011)EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2012.2638; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=EFSA_dup_-_15622037_15622038:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2652519061f61ed52035b53317999b8b
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =12.7 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635483:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_17e041ca2b6f8e630aa6b423ac0eaa48
ToxValDB_HESS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HESS NOAEL =96 mg/kg bw/day Rat oral subchronic; 90 days subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0de3e4b0a676289de295; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Urinalysis: Ket increase, Uro increase, Transitional epithelial cell increase, Epithelial cell casts|Blood Chemistry: gamma-GTP increase, Ca increase, TP increase, Alb increase, Glob increase, T-Cho increase|Absolute Organ Weight: Liver increase, Kidney increase, Testes increase|Relative Organ Weight: Liver increase, Kidney increase, Testes increase, Epididymis increase|Necropsy: Kidney: Pelvic dilatation, unilateral|Histopathology: Liver: Central hypertrophy of hepatocyte Liver: Peripheral hypertrophy of hepatocyte Liver: Myelinoid figure in the cytoplasm Kidney: Eosinophilic droplets(a-2U-globuline)Thyroid: Flaky appearance , colloid increase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|gross pathology|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=HESS:15638403:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f00a9f0b58cb91b393090cca2d61f6e1
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier A7NRR1HLH6 UNII - - - chemical {"approval_status":null,"molecular_formula":"C13H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"A7NRR1HLH6"}
openFDA substances FDA UNII substance identifier A7NRR1HLH6 UNII - - - chemical {"approval_status":null,"molecular_formula":"C13H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"A7NRR1HLH6"}
openFDA substances FDA UNII substance identifier A7NRR1HLH6 UNII - - - chemical {"approval_status":null,"molecular_formula":"C13H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"A7NRR1HLH6"}
openFDA substances FDA UNII substance identifier A7NRR1HLH6 UNII - - - chemical {"approval_status":null,"molecular_formula":"C13H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"A7NRR1HLH6"}