What is the NOAEL for Beta-Ionone?
Beta-Ionone has 8 NOAEL studies in the database. The lowest reported value is 12.7 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Beta-Ionone
Also known as: (3E)-4-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-3-buten-2-one, (E)-4-(2,6,6-Trimethylcyclohex-1-enyl)but-3-en-2-one, 2-07-00-00140, BRN 1909544, EINECS 201-224-3 (+14 more)
CAS 79-77-6
Beta-Ionone (CAS 79-77-6) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Beta-Ionone
CAS Number
79-77-6
DTXSID
DTXSID4021769
Molecular Formula
C13H20O
InChI Key
PSQYTAPXSHCGMF-BQYQJAHWSA-N
Monoisotopic Mass
192.151415
Synonyms
(3E)-4-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-3-buten-2-one(E)-4-(2,6,6-Trimethylcyclohex-1-enyl)but-3-en-2-one2-07-00-00140BRN 1909544EINECS 201-224-3trans-4-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-3-buten-2-oneUNII-A7NRR1HLH6(3E)-4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-one(E)-beta -ionone4-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-(E)-3-Buten-2-oneFEMA 2595Ionone, beta
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =12.7 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| A7NRR1HLH6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A7NRR1HLH6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A7NRR1HLH6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A7NRR1HLH6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =96 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HESS |
| =750 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =10 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_EFSA |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | (E)-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-buten-2-one | 201-224-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
BETA-IONONE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include Beta-Ionone?
Beta-Ionone appears on 3 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is Beta-Ionone used in cosmetics?
Yes, Beta-Ionone is also indexed as a cosmetic ingredient under the name Beta-Ionone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Beta-Ionone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Beta-Ionone used outside industrial chemicals?
Beta-Ionone also appears in cosmetics, pharmaceutical databases.