Also known as: Akneroxid 5, Asidopan, Aztec BPO, Benoxyl (5&10) Lotion, Benzoic acid, peroxide (+15 more)
CAS 94-36-0
Benzoyl peroxide (CAS 94-36-0) is a chemical substance with GHS signal word Danger; key hazard signal: H241; H319; H317; H400; H410. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC, OSHA, EPA TRI.
View cosmetic safety profile for Benzoyl Peroxide Regulatory & →
Benzoyl peroxide is classified GHS Danger (H241, H319, H317, H400, H410) in the chemicals database but is restricted in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1998 | 36, Sup 7, 71 |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Org. Perox. B; Eye Irrit. 2; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1 | H241; H319; H317; H400; H410 | GHS01; GHS02; GHS07; GHS09 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 5 mg/m³ | - | 5 | N |
| NIOSH | TWA | 5 mg/m³ | - | 5 | N |
| CAL/OSHA | TWA | 5 mg/m³ | - | 5 | N |
| NIOSH | IDLH | 1500 mg/m³ | - | 1500 | - |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Europe; Personal care; restricted | European Commission | CosIng |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 3.8 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 26.68 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 32.53 | ug/mL | CV70 | Dermal | - | NTP_ICE_skin_sensitization |
| 34.9 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 41 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 1.38 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 0.4 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| =39 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 100 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 81.3 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 90.65 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 41.5 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| >2000 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 0.0044 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 0.023 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| W9WZN9A0GM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| W9WZN9A0GM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| W9WZN9A0GM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| W9WZN9A0GM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| >49.8 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 567.6 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 567.63 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 1.36 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.4 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 2.28 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 36.23 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 14180 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 1956 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 567.1 | ug/cm2 | Induction dose per skin area, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| =7710 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 1000 | mg/kg bw/day | LOAEL | oral | rat | COSMOS_DB |
| 1.4 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 4.2 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 30 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| 280 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HESS |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 41 of 41 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dibenzoyl peroxide | 202-327-6 | ECHA overview → |
TRI hazard and reporting flags for the matched chemical.
| Chemical | Category | Flags |
|---|---|---|
| Benzoyl peroxide | - | - |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Benzoyl peroxide (CAS 94-36-0) is classified under EU CLP Annex VI as Org. Perox. B; Eye Irrit. 2; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H241; H319; H317; H400; H410. Source: EU CLP Annex VI (ECHA).
Benzoyl peroxide has 41 NOAEL studies in the database. The lowest reported value is 0.0044 % via Dermal in Mouse. Source: NTP_ICE_skin_sensitization.
Benzoyl peroxide appears on 8 regulatory/inventory lists including active_ingredient; Australia, inert_ingredient; non_food_use; Pesticides, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 5 more. Source: EPA CPDat.
Benzoyl peroxide is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Occupational exposure limits for Benzoyl peroxide are set by OSHA, NIOSH, CAL/OSHA. 4 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Benzoyl peroxide is also indexed as a cosmetic ingredient under the name Benzoyl Peroxide Regulatory &. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Benzoyl peroxide is classified GHS Danger (H241, H319, H317, H400, H410) in the chemicals database but is restricted in EU cosmetics.
Benzoyl peroxide also appears in cosmetics, pharmaceutical databases.